米非司酮与妈富隆治疗围绝经期功能失调性子宫出血的临床疗效比较

Comparison of Clinic Curatire Effect of Mifepristone and Marvelon Treating in Perimenopausal Dysfunctional Uterine Bleeding

目的:探讨米非司酮与妈富隆治疗围绝经期功能失调性子宫出血的临床疗效。方法:选取180例确诊为围绝经期功能失调性子宫出血患者的临床资料,随机分为两组,每组90例,米非司酮组患者口服米非司酮12.5mg/d,妈富隆组患者口服妈富隆,月经周期第1天起1片,连服21d。7d后再开始新的周期,连续治疗3个月,比较两组患者的子宫内膜变化情况及月经情况。结果:治疗后两组患者的子宫内膜厚度改变比较差异有统计学意义(P<0.05);妈富隆组患者在用药期间80例闭经。在停药后1个月有8例患者恢复月经。米非司酮组患者在用药期间有88例患者绝经,停药后1个月有6例患者恢复月经。结论:患者每天口服妈富隆临床疗效肯定、使用安全,值得在临床推广。

Objective：To explore the comparison of Mifepriston and Marvelon treatment of perimenopausal dysfunctional uterine bleeding of clinical efficacy.Methods：180 cases diagnosed as perimenopausal dysfunctional uterine bleeding in patients with clinical data,were randomly divided into two groups of 90 cases.The Mifepristone group was treated with Mifepristone 12.5mg/d,Marvelon group were treated with Marvelon,the first day of the menstrual cycle 1,with service 21.7 days after starting a new cycle of continuous treatment for 3 months,two groups were compared endometrial changes and menstruation.Results：After treatment,the changes in endometrial thickness were no significant difference（P0.05）;Marvelon group had amenorrhea in 80 cases during the treatment.A month after discontinuation of 8 patients resume menstruation.In Mifepristone group during the treatment 88 patients were postmenopausal.One month after treatment,6 patients resumed menstruation.Conclusion：Daily oral administration of Marvelon has a good effect and security,it is worthy of clinical application.