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A870G的多态性与肿瘤发生发展的相关性

Polymorphism of A870G with the development and progression of human tumors
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摘要 细胞周期蛋白D(1CCND1)是调控细胞周期的关键因子,其异常表达与多种肿瘤的发生、发展和预后有关。ccnD1基因A870G的多态性可能是导致CCND1高表达的原因之一,本文就A870G的多态性及其研究方法、A870G的多态性与肿瘤发生的相关性、A870G的多态性与肿瘤发展的相关性等研究进展作一综述。 Cyclin Dl（CCND1） is a key regulator in the cell cycle. Over＇expression of CCND1 protein significantly correlated with the development, progression and prognosis of various tumors. Recently, ccnD1 gene A870G polymorphism has been identified at nucleotide A870G. In this paper, the association of CCND1 A870G polymorphism with the development and progression of tumors is reviewed.
作者 刘唯佳 朱恩新 刘婷姣
机构地区 大连医科大学口腔医学院基础教研室
出处 《国际口腔医学杂志》 CAS 2012年第1期93-96,100,共5页 International Journal of Stomatology
基金 国家自然科学基金资助项目(30700955) 辽宁省科技厅博士启动基金资助项目(20071080) 大连市优秀青年科技人才基金资助项目(2008J23JH037) 教育部留学归国人员科研启动基金资助项目(2008890)
关键词 细胞周期蛋白D1 基因多态性 肿瘤 cyclin D1 gene polymorphism, tumor
分类号 R730.2 [医药卫生—肿瘤]
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参考文献45

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二级参考文献38

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国际口腔医学杂志
2012年 第1期

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