游走抑制因子及其在牙周疾病中的作用

Migration inhibitory factor and effect of its on periodontal diseases

游走抑制因子(MIF)是前炎症细胞因子成员之一,能抑制单核/巨噬细胞移动,参与调节多种生理、病理和免疫应答过程。本文就MIF的结构特点、MIF的表达模式、MIF的生理和病理学功能、MIF在牙周疾病中的作用等作一综述。

Migration inhibitory factor（MIF） is described as a potent pro-inflammatory mediator that inhibited the migration of macrophages, which plays an important role in the regulation of physiological, pathological and immunologic response processes. Special emphasis is placed on the emerging concept that MIF has a central role as a regulator of inflammatory responses, and the implications it might have for the development of periodontal diseases.