自体脂肪移植血供建立的研究进展

Research progress on microvascular angiogenesis in autologous fat graft

各种原因导致的软组织缺损,严重影响了患者的生理和心理健康,其修复和重建一直是整形和修复重建外科面临的重大挑战。自体脂肪移植具有来源丰富、取材方便、无免疫排斥反应等优点,是软组织修复重建的常用方法之一。然而,其远期的不稳定性和高吸收率极大地限制了这一技术在临床的更广泛应用。研究表明,移植区血供建立不足是导致移植脂肪组织高吸收率的关键原因之一。因此,如何促进脂肪移植的血供建立,提高移植体的存活率,是国内外研究的热点。本文就自体脂肪移植的血供建立进行探讨。

Soft tissue defects resulted from a variety of reasons not only lead to appearance disfigurement, but also seriously affect emotional well-being of patients, and is one of the most significant challenges in reconstructive and plastic surgery. Autologous fat graft has been popular in repair of soft tissue defects because of its rich material resources, convenience in obtaining, no immunity reaction and so on. But its unstability and significant resorption over time has greatly restricted its wider utilization in patients. The main problem is insufficient blood supply in fat grafts. So more and more researches focus on how to improve mierovascular angiogenesis and fat graft viability. Here we review recent studies that revealed the microvascular angiogenesis in autologous fat graft.