心源性脑栓塞出血性转化的临床因素分析

Risk factors of hemorrhagic transformation after cardiac cerebral infarction： a clinical analysis

目的：探讨心源性脑栓塞出血性转化（hemorrhagic transformation,HT）的临床危险因素.方法：回顾性分析我院2002年1月-2010年1月81例诊断为心源性脑栓塞的住院患者的临床和神经影像学资料,分为HT组和非HT组.共列入16项可能相关的出血性转化的影响因素进行单因素分析：包括年龄、性别、脑梗死面积、血脂、血糖、NIHSS评分等.结果：吸烟、大面积脑梗死、低密度脂蛋白降低、入院时血糖升高、以及入院时NIHSS评分在HT组和非HT组间有显著差异.结论：吸烟、大面积脑梗死、低密度脂蛋白降低、入院时血糖升高、以及入院时NIHSS评分高是心源性脑栓塞患者发生HT的主要危险因素.

ObjectiveTo explore the clinical risk factors of hemorrhagic transformation after cardiac cerebral infarction. Methods：The clinical anti neuroimaging data were analyzed retrospectively in 81 cardiac cerebral infarction patients that were divided into hemorrhagic transformation group and non-hemorrhagic transformation group from January 2002 to January 2010 in Dalian friendship hospital. 16 clinical items were evaluated,in cluded ： age, gender, smoking, cerebral infarction area, lipids, glucose, NIHSS score and so on. Results ： There were significant differences between HT group and non-- HT group in Smoking, cerebral infarction area, glucose, LDL, NIHSS scores. Conclusion ： Smoking, massive cerebral infarction, higher glucose,low LDL,higher NIHSS score were all associated with a greater risk of hemorrhagic transformation after cardiac cerebral infarction.