脑发育不全导致癫痫的外科治疗

Surgical treatment for epilepsy caused by cerebral dysgenesis

目的探讨对脑发育不全性癫痫的致痫灶评估和外科治疗。方法2005年5月至2009年8月对12例经临床表现、神经影像学、脑电图、PET／CT等确诊的脑发育不全性癫痫患者进行致痫灶评估、手术治疗，术后口服小剂量的卡马西平、丙戊酸钠或原术前服用的抗癫痫药。，结果出院后随访1．5—5．8年。按Engel术后标准评价Ⅰ级4例，Ⅱ级6例，Ⅲ级2例；按谭启富术后标准，满意者4例，显著改善者7例，良好1例。结论外科治疗脑发育不全性癫痫是一种非常有效的方法。

Objective To study the evaluation of epileptogenic zone and surgical treatment of cerebral dysgenesis epilepsy. Method According to clinical manifestation, neuroimaging, EECG and PET/ CT, 12 cerebral dysgenesis epilepsy cases got final diagnosis from May 2005 to August 2009. After epileptogenic zone evaluation and surgical treatment, low dose of Tegretol, Sodium Valproate pills （ or some antiepileptic drugs should taken preoperatively）were taken postoperatively. Results 12 patients were followed - up from 1.5 to 5.8 years to evaluate surgical effects by Engel classificatin standard（4 cases Engel Ⅰ ,6 cases Engel Ⅱ ,2 cases Engel Ⅲ ） and Tanqifu standard（ satisfactory in 4 cases, conspicuous improved in 7 and good in 1 ）. Conclusions Surgical treatment for cerebral dysgenesis epilepsy is effective.