组织芯片检测肝细胞癌中Ezrin蛋白的表达、定位及意义
被引量:2
摘要
膜细胞骨架连接蛋白Ezrin与包括肝细胞癌(hepatocellular carcinoma,HCC)在内的多种肿瘤的增殖、侵袭力、转移、临床预后有密切关系。我们利用组织芯片技术检测HCC及癌旁良性组织中Ezrin蛋白的表达,探讨在HCC及癌旁良性组织中表达的亚细胞定位特点、与临床病理因素的相关性及临床意义。
出处
《中华普通外科杂志》
CSCD
北大核心
2011年第12期1049-1051,共3页
Chinese Journal of General Surgery
基金
吉林省科技厅科技发展计划基金资助项目(200905203)
参考文献5
-
1高书颖,许丽艳,孟令英,崔磊,周飞,李恩民.ezrin基因在几种癌细胞中的表达及其5′侧翼区序列转录活性的鉴定[J].肿瘤防治研究,2008,35(1):1-4. 被引量:6
-
2Yeh CN,Pang ST,Chen TW,et al.Expression of ezrin is associated with invasion and dedifferentiation of hepatitis B related hepatocellular carcinoma.BMC Cancer,2009,9:233-242.
-
3Sizemore S,Clicek M,Sizemore N,et al.Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with Ezrin.Cancer Res,2007,67:6183-6191.
-
4Sun CX,Robb VA,Gutmann DH.Protein 4.1 tumor suppressors:getting a FERM grip on growth regulation.J Cell Sci,2002,115:3991-4000.
-
5Zeng HM,Xu LY,Xiao DW,et al.Altered expression of ezrin in esophageal squamos cell carcinoma.J Histochem Cytochem,2006,54:889-896.
二级参考文献2
-
1沈忠英,蔡维佳,沈健,许锦阶,岑山,滕智平,胡智,曾毅.人乳头状瘤病毒18E6E7和TPA协同诱发人胚食管上皮细胞恶性转化的研究[J].病毒学报,1999,15(1):1-6. 被引量:28
-
2Zhong-YingShen,Li-YanXu,Ming-HuaChen,En-MinLi,Jin-TaoLi,Xian-YingWu,YiZeng.Upregulated expression of Ezrin and invasive phenotype in malignantly transformed esophageal epithelial cells[J].World Journal of Gastroenterology,2003,9(6):1182-1186. 被引量:47
共引文献5
-
1高书颖,李恩民,孟令英,崔磊,袁华敏,杜则澎,许丽艳.肺癌细胞中调控ezrin基因基本转录活性的顺式作用元件及转录因子的鉴定[J].生物化学与生物物理进展,2009,36(3):288-296. 被引量:5
-
2高书颖,李恩民,杜则澎,陆晓峰,许丽艳.转录因子Sp1和Sp3对食管癌细胞ezrin基因的表达调控作用[J].中国免疫学杂志,2009,25(8):695-698. 被引量:3
-
3高书颖,李恩民,崔磊,孟令英,杜则澎,许丽艳.HeLa细胞ezrin基因基本启动子区转录调控元件的鉴定[J].肿瘤防治研究,2009,36(9):721-725.
-
4高书颖,李恩民,陆晓峰,杜则澎,许丽艳.siRNA干扰ERK1/2表达对食管癌细胞ezrin基因的转录调控作用[J].肿瘤防治研究,2010,37(5):491-494.
-
5郭秀璞,于洁,高书颖.鼻咽癌细胞中ezrin基因启动子上游序列转录调控特性的研究[J].细胞与分子免疫学杂志,2012,28(1):8-11.
同被引文献19
-
1MATITHEW J , HINES J E, OBAFUNWA J O , et al. CD44 is expressed in hepatocellular carcinomas showing vascular invasion [J]. J Pathol, 1996, 179 (1) : 74 - 79.
-
2BRAMBILLA E, TRAVIS W D, COLBY T V, et al. The new World Health Organization classification of lung tumours [J]. Eur Respir J, 2001, 6:1059 - 1068.
-
3ZHOU B, LENG J, HU M, et al. Ezrin is a key molecule in the metastasis of MOLT4 cells induced by CCL25/CCR9 [J]. Leuk Res, 2010, 34 (6) : 769 -776.
-
4YEH C N, PANG S T, CHEN T W, et al. Expression of ezrin is associated with invasion and dedifferentiation of hepatitis B related hepatocellular carcinoma [ J ]. BMC Cancer, 2009, 9: 233.
-
5ZHENG S, HUANG J, ZHOU K, et al. 17β -Estradiol enhances breast cancer cell motility and invasion via extra - nuclear activation of actin - binding protein ezrin [ J ]. PLoS One, 2011, 6 (7) : e22439.
-
6MIELGO A, BRONDANI V, LANDMANN L, et al. The CD44 standard/ezrin complex regulates Fas -mediated apoptosis in Jurkat ceils [J]. Apoptosis, 2007, 12 ( 11 ) : 2051 - 2061.
-
7WICK W, GRIMMEL C, WILD -BODE C, et al. Ezrin dependent promotion of glioma cell clonogenicity, motility, and invasion mediated by BCL- 2 and transforming growth factor- beta2. J Neurosci, 2001,21 (10) : 3360 - 3368.
-
8CREPALDI T, GAUTRAU A, COMOGLIO P M, et al. Ezrin is an effector of hepatocyte growth factor - mediated migration and morphogenesis in epithelial cells [ J ]. J Cell Biol, 1997, 138 (2) : 423 -434.
-
9YUNXIAO MENG, ZHAOHUI LU, SHUANGNI YU et al. Ezrin promotes invasion and metastasis of pancreatic cancer cells [J]. J Transl Med, 2010, 23 (8) : 61 - 73.
-
10ERWIG L P, MCPHILIPS K A, WYNES M W, et al.Differential regulation of phagosome maturation in macro- phages and dendritic cells mediated by Rho GTPases and ezrin - radixin - moesin (ERM) proteins [ J]. Proc Natl Acad Sci U S A, 2006, 103 (34) : 12825 -12830.
二级引证文献3
-
1林黎娟.癌基因DEK蛋白表达判断肺鳞状细胞癌预后的临床价值[J].辽东学院学报(自然科学版),2013,20(3):189-193. 被引量:2
-
2张贺.大气混合污染物对大鼠肺脏中血红素氧合酶1表达的影响[J].辽东学院学报(自然科学版),2013,20(4):247-252. 被引量:1
-
3王世卿,谭燕,孔繁勇,王研,董光宇,张锦辉,林黎娟.结直肠癌中原癌基因DEK与IMP3/Ezrin通路的相关性[J].辽东学院学报(自然科学版),2016,23(3):207-211. 被引量:2
-
1刘友生,晏良遂,傅国金,李爱莲.烧伤后肠源性标记内毒素在主要内脏器官的分布及肝脏亚细胞定位[J].中华创伤杂志,1995,11(3):166-168. 被引量:1
-
2吕文平,董家鸿,黄志强.肝移植时代肝细胞癌的外科治疗[J].中华普通外科杂志,2008,23(7):555-558. 被引量:2
-
3盛茂林,许戈良,荚卫东.维生素D及类似物与肝细胞癌相关性研究进展[J].中华普通外科杂志,2011,26(6):528-530. 被引量:2
-
4杨正汉,周诚,杨大为.肝细胞癌局部微创治疗后的CT、MRI评价[J].中华放射学杂志,2010,44(12):1239-1243. 被引量:10
-
5陈规划,傅斌生,杨扬.肝癌肝移植——热点和争议[J].消化肿瘤杂志(电子版),2009,1(2):79-81.
-
6Guang-Wen Zhou, Wei-Ding Wu, Wei-Dong Xiao, Hong-Wei Li and Cheng-Hong Peng Shanghai, China Department of Surgery, Shanghai Institute of Diges- tive Surgery, Ruijin Hospital, Shanghai Second Medical University, Shang- hai 200025, China.Pancreatectomy combined with superior mesenteric-portal vein resection: report of 32 cases[J].Hepatobiliary & Pancreatic Diseases International,2005,4(1):130-134. 被引量:6
-
7孙艳军,孟翔凌,陈伟.32例老年人原发性胆囊癌的诊治[J].安徽医科大学学报,2010,45(1):133-134. 被引量:3
-
8周福庆,彭贵主.肝癌肝移植预后的临床研究进展[J].中华肝胆外科杂志,2008,14(10):751-752. 被引量:2
-
9杨妙芳,谢渭芬.肝癌中信号转导通路的研究进展[J].中华消化杂志,2012,32(8):573-576. 被引量:2
-
10曹珮华,李蔚勃,曹峻岭.连接蛋白与大骨节病[J].国外医学(医学地理分册),2005,26(4):145-147.