Hedgehog信号通路对胰腺癌细胞上皮间质转化的调控作用
摘要
Hedgehog（Hh）信号通路及上皮问质转化（epithelialmesenchymaltransition，EMT）调控细胞的增殖和分化，在胚胎发育过程中均发挥重要作用。正常成人组织中二者活性均明显下降，其异常活化往往与恶性肿瘤的发生、发展、侵袭及转移密切相关。在胰腺癌细胞中常发现有Hh信号通路的异常活化和EMT现象，本文就Hh信号通路调控胰腺癌细胞EMT的作用及其机制做一综述。
出处
《中华胰腺病杂志》
CAS
2011年第6期446-448,共3页
Chinese Journal of Pancreatology
基金
基金项目：国家自然科学基金（30972897）
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