乳腺癌手术前后检测血清CA153、HCY和VEGF的临床意义

Clinical significance of combined detection to serum levels of CA153,HCY and VEGF before and after operation to breast cancer patients

目的探讨乳腺癌患者手术治疗前后血清糖类抗原(CA153)、同型半胱氨酸(HCY)和血管内皮生长因子(VEGF)水平的变化及其临床意义。方法应用放射免疫分析法和酶联法对36例乳腺癌患者手术前后的血清CA153、HCY和VEGF水平进行检测,并与35名行体检的健康者进行比较。同时对三者联检与单检的敏感性和特异性进行比较。结果乳腺癌患者术前的血清CA153、HCY和VEGF水平显著高于健康人组(P<0.01),术后1个月明显下降至正常。术后2年内复发的5例血清CA153、HCY和VEGF水平又恢复至术前水平(P<0.05)。CA153、HCY、VEGF三者联检的敏感性、特异性分别为89.5%和92.4%,好于单检的敏感性和特异性。结论血清CA153、HCY和VEGF水平的变化可作为乳腺癌患者诊断和疗效观察的监测指标,且三者联检的敏感性及特异性更高。

Objective To dicuss the clinical significance of combined detection serum levels of CA153, HCY and VEGF before and after operation to breast cancer patients. Methods Serum levels of CA153, HCY and VEGF before and after operation in 36 breast cancer cases were deteimined by radioimmunoassay and ELISA. Serum concentration changes were compared with 35 healthy subjects. Then we compared the sensitivity and specificity between combined detection and single detection. Results Serum levels of CA153. HCY and VEGF in the breast cancer patients before operation were significantly higher than those in the healthy subjects （P 〈 0. 01 ） , and decreased to normal level a month after surgery. 2 years after operation the serum levels in 31 patients without recurrence decreased markedly and closed to those in healthy subjects, and in the 5 patients with recurrence, the serum levels, increased again and closed to those before operation. The sensitivity and specificity of combined detection to serum levels of CA153, HCY and VEGF were 89.5% and 92.4% respectively,and higher than single detection. Conclusions Serum levels of CA153, HCY and VEGF might be useful in predicting operation effect and prognosis of breast cancer patients.