四川省青神县基本消除丝虫病后巩固措施远期效果观察

Strengthening Control Measures of Post-eradication of Lymphatic Filariasis in QingshenCounty,Sichuan Province

目的了解青神县基本消除丝虫病后实施巩固措施的远期效果,评价消除丝虫病后的流行趋势和慢性丝虫病患者的变化。方法采用单纯反复查治残存传染源的防治措施;采取复查补查、复治补治、集体服药和以重点人群与防治薄弱村组为主要监测对象的巩固措施;开展后期慢性丝虫病调查和复查及横向人群监测。结果青神县1983年基本消除丝虫病,1984年在疫点人群587人和横向人群1 100人监测中分别新检出微丝蚴血症者3、3例,微丝蚴密度为1～8条/120μl、2～13条/120μl;1985年横向人群监测检出复阳1例,微丝蚴密度19条/1 201。随着巩固措施实施,1986年以来已连续26年未检出微丝蚴血症者。原慢性丝虫病患者由基本消除丝虫病前的37例,减少至2010年的12例,1988年以来无新发慢性丝虫病发生。遗留的慢性丝虫病患者表现为高龄化、病程长的特点。结论青神县消除丝虫病后监测,未发现内源性传染源,显示实施巩固措施后远期效果显著,原流行区1988年以后出生人群得到了有效保护。后期工作重点应放在对输入性传染源的监测和原慢性丝虫病患者给予关怀与照料。

Objective To evaluate the prevalent trend of filariasis and the prognosis of chronic filariasis by understanding the long - term effect of implementation of strengthening control measures on maintenance of lymphatic filariasis basic eradication in Qingshen county. Methods Comprehensive control measures including continuous, repeated examination, treatment of residual lymphatic filariasis patients, implementation of mass drug treatment and surveillance of high - risk population of remo larial eradication. te village, were performed to monitor the prognosis of chronic filariasis patients and maintenance of fiResults During the surveillance in 1984 after announcement of basic elimination of lymphatic filariasis in Qingshen county, totally 3 patients with microfilaria density of 1 - 8 and 2 - 13 per 120 μl blood were found in 578 people in endemic area and in 1100 people in surrounding area, respectively. Only 1 original patient remained positive with 19 microfilaria/120 μl blood in the surrounding area in 1985. With the implementation of strengthening control measures, no microfilaria has been determined in any people for consecutive 26 years since 1986. The chronic infection patients have been dropped from 37 before announcement of filariasis basic eradieation to 12 in 2010.. No new chronic patient had been found since 1988. The residual chronic patients were featured in old - age and long - term course. Conclusion No local infectious patient was found in Qingshen county after eradication of lymphatic filariasis, indicating the significant long - term effectiveness of the implementation of strengthening control measures. The population born after the year 1988 has been effectively proretted. Further works should focus on the surveillance of imported patient and the care of existing chronic patients.