2型糖尿病踝肱指数和颈动脉内中膜厚度关系

Clinical Observation of Relationship between Ankle-brachial Index and Intima-media Thickness in Patients with Type 2 Diabetes Mellitus

目的观察2型糖尿病患者踝肱指数(ABI)和颈动脉内中膜厚度(IMT)关系。方法对106例2型糖尿病患者采用MD2多普勒血流探测仪测定ABI,并依据ABI分为外周动脉疾病(PAD)组(ABI≤0.9)和非外周动脉疾病(NPAD)组(ABI>0.9),同时采用飞利浦M2540A彩色超声检查仪检测所有患者IMT,进行组间比较,并对二者进行线性相关分析。结果 ABI≤0.9者72例,占14.78%;与NPAD组比较,PAD组IMT异常率显著增高(P<0.01);相关分析显示,2型糖尿病患者ABI与IMT呈显著负相关。结论 ABI和IMT检查可作为筛查2型糖尿病患者周围血管病变与糖尿病合并颈动脉粥样硬化的方法,二者常并行出现,可联合作为筛查糖尿病大血管病变的方法。

Objective To investigate the relationship of ankle-brachial index （ABI） and intima-media thickness in type 2 diabetics. Methods ABI Was examined in the 106 patients with type 2 diabetes mellitus using MD2 doppler flow detectors. All the patients were divided into peripheral arterial disease （PAD） group （ABI ≤ 0.9） and nonperipheral arterial disease group （ABI 〉0.9） according to the values of ABI. At the same time, IMT of all patients was examined with Philips M2540A color ultrasound examination mode. To compared them within groups and analyse linear dependence of determination result. Results Among the 106 patients, 78 patients had PAD（14.78%）. Compared with NPAD group, abnormal rate of IMT increased significantly in PAD group （P〈0.01）; correlation analysis showed that ABI was negatively related to IMT in type 2 diabetics mellitus. Conclusion ABI and IMT can be used as indexes for screening peripheral arterial disease and type 2 diabetes mellitus combined with carotid atherosclerosis in patients with type 2 diabetes mellitus respectively. ABI can be combined with IMT to screen diabetes macroangiopathy because of their parallel appear.