造孔剂对电泳沉积制备多孔HA涂层及其生物活性的影响

Fabrication and Bioactivity of Porous Hydroxyapatite Coating by Electrophoretic Deposition Using Different Porogens

采用水热法制得的羟基磷灰石(HA)纳米粉体,分别与造孔剂葡萄糖(Glu)、壳聚糖(CS)、炭粉(C)3种微粒(<38.5μm)配置成质量比1∶1的悬浮液,电泳沉积-烧结制备钛基多孔HA涂层,并对制得的3种多孔HA涂层在模拟体液浸泡前后的表面形貌、化学组成及物相变化进行表征。结果表明,经700℃烧结处理后制得的3种多孔HA涂层在1.5倍人体模拟体液中浸泡5 d后,多孔HA涂层表面均被层状生长的碳磷灰石颗粒完全覆盖,颗粒直径在5～25μm,说明这些多孔HA涂层均具有良好的生物活性。其中以CS为造孔剂制得的多孔HA涂层结合强度最高,达19.5 MPa,有望开发成为新型的人骨植入生物陶瓷材料。

To improve the bioactivity a：nd adhesion strength of hydroxyapatite （HA） coatings on titanium substrate, porous nano-HA coatings were deposited on titanium substrate using porogens such as glucose, starch and chitosan by electrophoretic deposition and sintering processes. The changes of surface morphology, chemical composition and phase composition of the porous HA coatings before and after immersion in simulated body fluid （SBF） were also investigated. The results showed that the porous HA coating was obtained by sintering at 700℃. These porous HA coating surfaces were covered by carbonate-apatite particles after immersion in 1.5 times ion concentration of SBF for 5 days, with diameter about 5 - 25 μm, indicating that these coatings possessed an excellent bioactivity on its surface. The adhesion strength between coating and substrate was up to 19.5 MPa using CS as porogens. The developed method is promising to develop new implant bioceramic materials of human bone.