一种合成3,5-二氨基吡啶及3,5-二甲氧羰基氨基吡啶的新路线

A New Synthetic Route to 3,5-Diaminopyridine and 3,5-Dimethoxycarbonylamino-pyridine

以3,5-二甲基吡啶为原料,经氧化、酰胺化,酰胺在不同的霍夫曼降解条件下合成3,5-二氨基吡啶及3,5-二甲氧羰基氨基吡啶,总收率分别为64%和68%。利用1H NMR、MS/MS和IR等测试技术对各化合物的结构进行了表征。讨论了氧化反应及霍夫曼降解反应的主要影响因素。反应均在常压下进行,反应条件温和,后处理简单,收率较高。

3, 5-Diaminopyridine and 2;, 5-dimethoxycarbonylamino-pyridine were prepared from 3, 5- dimethylpyridine in three steps including oxidation of methyl, amination and Hofmann degradation with the total yield of 64% and 68%, respectively. The reaction conditions of every step were studied and the intermediates and target compounds were characterized by 1H NMR, MS/MS, and IR. The reactions proceed under atmosphere pressure with mild reaction conditions, easy post treatment and high efficiency.