49份非正规来源哮喘药物中糖皮质激素成分和含量测定

Composition and content determination of glucocorticoids on 49 informal source-asthma drugs

目的通过高效液相色谱法（HPLC）对非正规来源支气管哮喘（简称哮喘）药物中的糖皮质激素进行初步的定性、定量测定。方法收集住院患者携带的非正规药物496份，随即抽取49份，采用HPLC法对药物中的糖皮质激素成分进行初步的定性、定量测定，并对结果进行统计学分析，结果以X±S表示。结果49种药物中有41种药物含有激素成分，阳性率为84％，其中，21种药物含有醋酸泼尼松，4种药物检测出泼尼松，7种药物检测出地塞米松，9种药物检测出醋酸地塞米松，8种药物未检测到任何糖皮质激素；经过定量分析，患者每日的激素摄入量相当于强的松11～22mg，平均（16．88±5．76）mg。结论经过定性、定量分析，可以初步确定非正规来源哮喘药物当中大部分含有糖皮质激素，长期服用将对患者造成较大的不良反应。

Objective To make quantitative and qualitative determination of glucocorticoids on 49 asthma drugs from informal sources with high performance liquid chromatography （HPLC）, and promote regular treatment of asthma. Methods Collect 496 informal source-asthma drugs carried by patients, and extract 49 from these drugs randomly. Make quantitative and qualitative determination of glucocorticoids on these drugs with HPLC, and make statistical analysis of the results, which will be shown by x± s . Results 41 drugs contain glucocorticoids, which is 84% of the 49, with 21 containing prednisolone acetate,4 prednisone,7 dexamethasone,9 dexamithasone acetate, and 8 containing none of them. We can see from the quantitative analysis results that, the intake of glucoeorticoids patients take daily is about 11 to 22 mg prednisolone, with an average of （16.12 ±5.23） mg. Conclusions After the qualitative and quantitative analysis of the drugs, we can initially determine that most of the informal-source asthma drugs contain glucocortieoids, of which can make great side effects to patients with long-term application.