氟康唑注射液与乳酸左氧氟沙星氯化钠注射液的配伍稳定性考察

Compatible Stability of Fluconazole Injection with Levofloxacine Lactate and Sodium Chloride Injection

目的:考察氟康唑注射液与乳酸左氧氟沙星氯化钠注射液配伍的稳定性。方法:考察20℃下8h内氟康唑注射液与乳酸左氧氟沙星氯化钠注射液配伍后,其配伍液的外观、pH值、不溶性微粒变化,并用高效液相色谱法测定药物的含量。结果与结论:氟康唑注射液与乳酸左氧氟沙星氯化钠注射液配伍后8h内的含量、pH值、外观及不溶性微粒均无明显变化。

OBJECTIVE： To study the compatible stability of Fluconazole injection and Levofloxacine lactate and sodium chlo- ride injection. METHODS： The change of appearance, pH value and indissoluble particle in the mixture within 8 h at 20 ℃ were observed after Fluconazole injection combined with Levofloxacine lactate and sodium chloride injection. The contents of drugs were determined by HPLC. RESULTS ＆ CONCLUSION： No significant change was found in content, pH value, appearance and indissoluble particle in 8h after Fluconazole injection combined with Levofloxacine lactate and sodium chloride injection.