摘要
目的:观察补肾活血方对强直性脊柱炎(AS)患者细胞核因子-κB受体活化因子配体(RANKL)、护骨素(OPG)的影响。方法:将65例AS患者随机分为2组:西医组(32例)采用柳氮磺胺吡啶治疗;中西医结合组(33例)采用补肾活血方联合柳氮磺胺吡啶治疗,均治疗3月。运用ELISA法测血清RANKL、OPG、骨钙素(OC)、Ⅰ型胶原C端肽(CTX)的表达水平。结果:2组治疗后血清RANKL含量均较治疗前明显下降(P<0.05,P<0.01),OPG含量均较治疗前明显升高(P<0.05),RANKL/OPG比值显著下降(P<0.05,P<0.01)。治疗后2组RANKL、RANKL/OPG比值比较,差异也有显著性意义(P<0.05)。治疗后2组血清OC水平均较治疗前显著升高(P<0.05,P<0.01),CTX水平均较治疗前显著降低(P<0.05,P<0.01),且中西医结合组OC水平变化更为显著(P<0.05)。结论:补肾活血方影响R ANKL/R ANK/OPG系统可能是其阻止AS骨质破坏的作用机理之一。
Objective： To observe the effect of Bushen Huoxue Decoction on receptor activator of nuclear factors-kappa B ligand （RANKL）and osteoprotegerin（OPG） in patients with ankylosing spondylitis （AS）. Methods：Sixty-five patients with AS were randomized into two groups. Western medicine group （n=32） was treated with sulfasalazine （SSZ） for three months. Combination group （n=33） was treated with Bushen Huoxue Decoction combined with SSZ for three months too. Serum levels of RANKL, OPG, osteocalcin（OC） and C-terminal cross-linking telopeptide of type I collagen （CTX）were detected by ELISA. Results： Serum RANKL levels was decreased obviously in both groups after treatment（P 〈 0.05, P 〈 0.01compared with that before treatment）.Serum OPG level was elevated significantly in both groups after treatment（P 〈 0.05）. RANKL/OPG ratio was decreased obviously in both groups after treatment （P 〈 0.05, P 〈 0.01 compared with that before treatment）. There was significant difference between the two groups after treatment（P 〈 0.05）.Serum OC level was elevated obviously and serum CTX level was decreased obviously after treatment （P 〈 0.05, P 〈 0.01 compared with those before treatment）. There was significant difference between the two groups after treatment in serum OC level （P 〈 0.05）. Conclusion. Bushen Huoxue Decoction has an effect on regulating RANKL/RANKL/OPG system, which may be one of its mechanisms in preventing bone destruction in AS patients.
出处
《新中医》
CAS
2012年第1期55-57,共3页
New Chinese Medicine
关键词
强直性脊柱炎
中医疗法
补肾活血方
Ankylosing Spondylitis
TCM Therapy
Bushen Huoxue Decoction
