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依帕司他治疗2型糖尿病早期肾病的临床研究 被引量：3

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摘要 目的观察依帕司他治疗2型糖尿病早期肾病的效果。方法将57例伴有微量白蛋白尿的2型糖尿病患者随机分为依帕司他治疗组(观察组,30例)和常规治疗组(对照组,27例),治疗前后测定尿微量白蛋白排泄率(urinary albumin ex-cretion rates,UAER)、血浆内皮素-1(endothelin,ET-1)及血清一氧化氮(NO)水平。结果与治疗前比较,观察组UAER及ET-1均显著降低(P<0.01),NO明显升高(P<0.01)。治疗过程中未出现明显不良反应。对照组UAER、ET-1及N0与治疗前比较差异无统计学意义(P>0.05)。结论依帕司他能减少2型糖尿病肾病(diabetic nephropathy,DN)患者尿微量白蛋白的排泄。
作者 戚文群
机构地区 江苏省泰州高港人民医院内分泌科
出处 《实用临床医药杂志》 CAS 2011年第21期102-102,106,共2页 Journal of Clinical Medicine in Practice
关键词 2型糖尿病 早期肾病 内皮素 一氧化氮 依帕司他
分类号 R587.1 [医药卫生—内分泌]
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参考文献4

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共引文献1726

同被引文献32

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二级引证文献21

实用临床医药杂志
2011年 第21期

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