白首乌甙A、B和C的结构

CYNAURICUOSIDES A, B AND C, STEROID GLYCOSIDES FROM THE ROOT OF CYNANCHUM AURICULATUM

从著名中药白首乌(Cynanchum auricutatum Royle ex Wight)根中分离得到7个C_2(?)体甙。其小4个已知物——wilfosidc C3N (Ⅰ), C1N (Ⅱ), C1G (Ⅲ), K1N (Ⅴ),和另外3个新C_(21)甾体甙,命名为白首乌甙A (Ⅵ),B (Ⅶ),C(Ⅳ) (cynauricusidc A, B,C)。经光谱数据分析和化学反应,证明其结构分别为:开德甙元 3-氧-β D-葡萄糖吡喃基-(1→4)-α-L-加拿大麻糖吡喃基-(1→4)-β-D-加拿大麻糖吡喃基-(1→4)-α-L-迪吉糖吡喃基-(1→4)-β-D-加拿大麻糖吡喃甙(kidjoranin 3-O-β-D-glucopyranosyl-(1→4)-α-L-cymaropyranosy-(1→4)-β-D-cymaropyranosyl-(1→4)-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranoside, Ⅵ);萝藦甙元 3-氧-α-L-加拿大麻糖吡喃基-(1→4)-β-D-加拿大麻糖吡喃基-α-L-迪吉糖吡喃基-(1→4)-β-D-加拿大麻糖吡喃甙(metaplexigenin -O-α-L-cymaropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-α-L-diginopyranosyl-(1→4)-β-cymaropyranoside,Ⅶ);告达庭 3-氧-β-D-葡萄糖吡喃基-(1→4)-β-L-葡萄糖吡喃基-(1→4)-α-L-加拿大麻糖吡喃基-(1→4)-β-D-加拿大麻糖吡喃基-(1→4-α-L-迪吉糖吡喃基-(1→4)-β-D-加拿大麻糖吡喃基(caudatin 3-O-β-D-glucopyranosy-(1→4)

From the root of Cynanchum auriculatum Royle ex Wight, besides four known glycosides-wilfoside C 3 N (Ⅱ) , C1N (Ⅱ) , C1G (Ⅲ) , K1N (V.) , three new C21 steroid glycosides named cynauricuricuosidc A (Ⅵ) ,B (Ⅵ) ,C (Ⅳ) were isolated. On the basis of chemical and spectral evidence, their structures were deduced as kidjoranin 3 - 0 -β-D-glucopyranosyl- (1→4) -α-L-ymaropyranosyl- (1←4) -β-D-cy maropyran-osyl- (1→4) -α-L-diginopyranosyl- ( 1→4 ) -β-D-cymaropyransidc (Ⅵ) ; mctaplcxige-nin 3 - 0-α-L-eymaropyranosyl- ( 1→4 ) -β-D-cymaropyranosyl- (1→4) -α-L-digino-pyranosyl- ( 1→4) -β-D-cymaropyranosidc (Ⅶ) ; caudatin 3 - 0 -β-D-glucopy ranosyl-(1→4 ) -β-D-glucopyranosyl- ( 1→4) -α-L-cymaropyranosyl- ( 1→4 ) -β-D--cymarop-yranosyl- (1→4) -α-L-diginopyranosyl- ( 1→4) -β-D-cymaropyranosidc (Ⅳ) ,respee-tively.