稳定型心绞痛患者血清HMGB1水平与冠脉粥样硬化斑块稳定性的相关性研究

Research on the correlation of serum high-mobility group Box-1 (HMGB1) levels and coronary plaque vulnerability in patients with stable angina pectoris

目的:探讨稳定型心绞痛(SAP)患者血清高迁移率族蛋白1(HMGB1)水平与冠脉粥样硬化斑块稳定性的关系。方法:本研究共纳入266例SAP患者。根据患者是否存在不稳定斑块将所有患者分为稳定斑块组(n=121)及不稳定斑块组(n=145),采用酶联免疫吸附(ELISA)法测患者的血清HMGB1水平。结果:不稳定斑块组血清HMGB1水平[6.17(2.83～11.62)ng/ml]较稳定斑块组[4.23(1.73～7.50)ng/ml]明显升高(P<0.01),多元Logistic回归分析显示高血清HMGB1水平与SAP患者存在不稳定斑块呈独立正相关(OR=2.336,95%CI=1.207～3.988,P<0.05)。结论:血清HMGB1是SAP患者存在不稳定斑块的独立危险因子,血清HMGB1有望成为预测SAP患者冠脉粥样硬化斑块稳定程度的生物学标志物。

Objective：To determine the relationship between serum high-mobility group box 1（HMGB1） levels and coronary plaque vulnerability in patients with stable angina pectoris（SAP）.Methods：A total of 266 SAP patients were enrolled in the present study.All the patients were classified as stable plaques group（n=121） or vulnerable plaques group（n=145） based on coronary plaque morphology.Serum HMGB1 levels were determined by enzyme-linked immunosorbent assay（ELISA）.Results：Serum HMGB1 levels were significantly higher in patients with vulnerable plaques [6.17（2.83-11.62）ng/ml] than those in patients with stable plaques [4.23（1.73-7.50）ng/ml]（P〈0.01）.Multivariate Logistic regression showed that serum HMGB1 levels was independently and positively associated with the presence of vulnerable plaques（OR=2.336,95%CI=1.207-3.988,P0.05） in SAP patients.Conclusion：Serum HMGB1 is the independent risk factor for vulnerable plaques in SAP patients.These results indicate that serum HMGB1 might be a potential biomarker for predicting coronary plaque vulnerability in SAP patients.