冠状动脉粥样硬化患者无创性检测指标的变化与意义

Research on the changes of non-invasive detection index in patients with coronary artherosclerosis

目的通过对入选患者行内皮功能、动脉弹性等方面多种无创指标的检测,评价这些指标在冠脉早期病变患者中的变化情况及临床意义。方法对入选的123例患者行冠脉造影患者,根据冠脉造影的结果分为正常对照组、早期冠状动脉病变组、冠状动脉粥样硬化组,检测各组多种无创性检测指标(NO、ET-L、VWF、baPWV、cIMT、hs-CRP)。结果与正常对照组比较,早期冠状动脉病变组和冠状动脉粥样硬化组的NO水平下降,ET-L、VWF、baPWV、cIMT、hs-CRP等指标呈升高趋势。Logistic回归分析发现,baPWV、NO、ET-1是影响冠状动脉粥样硬化病变的相关因素。结论内皮功能受损、动脉弹性等方面多种无创指标的改变参与了冠状动脉粥样硬化的发生与发展。

Objective To investigate the changes of non- invasive detection indexes in en- dothelial function, arterial flexibility in patients non- invasive detection index. Methods 123 pa- tients with coronary artherosclerosis were given coronary angiography. According to the results of the coronary angiography, they were divided into three groups： the normal group, early coronary artery disease group and coronary atherosclerosis group. These non - invasive detection indexes （NO, ET- L, VWF, baPWV, cIMT, hs- CRP） were determined. Results Compared with the normal group, NO Levels in early coronary artery disease group and coronary atherosclerosis group decreased, while such levels of ET - L, VWF, baPWV, cIMT, hs - CRP presented increasing ten- dency. According to Logistic, baPWV, NO and ET- 1 is related with coronary atherosclerosis. Conclusion The changes of non- invasive detection indexes in endothelial function and arterial flexibility were involved in the occurrence and development of coronary atherosclerosis.