TPF方案诱导化疗加同期调强放化疗治疗局部晚期鼻咽癌近期疗效观察

The short-term efficacy of TPF induction chemotherapy followed by concurrent chemo-radiotherapy with intensity-modulated radiation therapy for locally advanced nasopharyngeal carcinoma

目的探讨TPF方案诱导化疗加同期调强放化疗治疗局部晚期鼻咽癌的近期疗效。方法本研究对46例经病理确诊的局部晚期鼻咽癌患者采用TPF方案诱导加化疗同期调强放化疗治疗,观察并记录近期疗效以及1、2年生存率,1、2年无局部复发生存率,1、2年无区域进展生存率等指标。结果治疗的总有效率为82.61%;1、2年总体生存率分别为91.30%、84.78%;1、2年无局部复发生存率分别为86.96%、80.43%;1、2年无区域进展生存率分别为91.30%、82.61%;主要毒副作用为骨髓抑制、脱发及消化道反应。结论 TPF方案诱导化疗加同期调强放化疗治疗局部晚期鼻咽癌的近期疗效良好,毒副反应小,容易被患者接受,可以临床广泛应用。

Objective To explore the short- term efficacy of TPF induction chemotherapy followed by concurrent chemo- radiotherapy intensity - modulated radiation therapy for locally ad- vanced nasopharyngeal carcinoma. Methods Forty - six cases of pathologically confirmed locally advanced nasopharyngeal carcinoma were treated with TPF induction chemotherapy followed by concurrent chemo - radiotherapy intensity - modulated radiation therapy. The short - term efficacy and 1 to 2 - year survival rate, 1 to 2 - year local relapse- free survival rate and 1,2 - year regional progression - free survival rate were observed and recorded. Results The total response rate was 82.61%. The total survival rates of 1, 2 years were 91.30% and 84.78% respectively. The local relapse- free survival rate of 1, 2 years were 86.96 % and 80.43 % respectively. The regional pro- gression - free survival rates of 1 to 2＇, years were 91.30% and 82.61% respectively. The main toxic effects were bone marrow suppression, hair loss and gastrointestinal reactions. Conclusion The TPF induction chemotherapy followed by concurrent chemo - radiotherapy intensity- modulated ra- diation therapy for locally advanced nasopharyngeal carcinoma has good short- term efficacy and slight toxicity and is easily accepted by patients. It can be widely used clinically.