甲状腺过氧化物酶抗体和孕妇甲状腺功能障碍的筛查

Screening and analysis of thyroid peroxidase antibody and thyroid stimulating hormone in pregnant woman

目的探讨产前孕妇甲状腺过氧化物酶抗体和促甲状腺素筛查的重要性。方法根据甲状腺功能测定结果,将孕妇分为甲状腺功能紊乱组(Ⅰ组)53例,非甲状腺功能紊乱组(Ⅱ组)49例,采用电化学方法检测孕妇血清TPO-Ab和甲状腺激素TSH水平。结果Ⅰ组TOP-Ab阳性率高达79.24%,Ⅱ组TOP-Ab阳性率高达10.20%;47例孕妇TPOAb阳性,其中有10例TSH异常(21.3%),55例TPOAb阴性,其中4例TSH异常(7.5%)。结论 TPOAb阳性孕妇甲状腺功能紊乱明显增加,TPOAb阳性孕妇的甲状腺功能有向亚临床甲状腺功能减退的趋势。

Objective To investigate importance of screening of thyroid peroxidase antibody and thyroid stimulating hormone. Methods According to the testing results of thyroid function, the pregnant women were divided into two groups. There were 53 cases of thyroid function and 49 cases of thyroid dysfunction. The level of TPO-Ab and TSH were detected by ECLIA. Results Posi- tive rate of TPO - Ab in thyroid function group was 79.24 %, and positive rate of TPO - Ab in thy- roid dysfunction group was 10.20%. The TPO- Ab results of 47 pregnant women were positive, in which the results of 10 TSH examples were exceptional （21.3%）, 55 TPO - Ab negative and 4 TSH were exceptional （7.5%）. Conclusion The thyroid function of pregnant women with posi- tive TPO- Ab is in disorder, and the TPO- Ab positive pregnancies show the tendency of sub- clinical hypothyroidism.