期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

硼中子俘获疗法进展和展望 被引量：2

原文传递
导出
摘要 硼中子俘获疗法（boronneutroncapturetherapy，BNCT）的基本原理是基于核裂变反应。当非放射性硼（10B）元素受到低能量中子照射后即发生核裂变，从而产生高能量α粒子（^4He），其本身衰变为锂（^7Li）核[^10B（n，α）^7Li]。^7Li核和α粒子的射程大约只有1个细胞的直径（10μm），所以其引起的损伤范围也仅局限于带有^10B的细胞。因此，
作者 杨伟廉 Rolf F．Barth 霍天瑶 周永茂 刘彤
机构地区 DepartmentofPathology 中国中原对外工程有限公司 北京凯佰特科技有限公司
出处 《中华放射肿瘤学杂志》 CSCD 北大核心 2012年第1期76-79,共4页 Chinese Journal of Radiation Oncology
关键词 硼中子俘获疗法 中子照射 非放射性 核裂变 Α粒子 低能量 高能量 细胞
分类号 R318.08 [医药卫生—生物医学工程]
  • 相关文献

参考文献24

  • 1Barth RF,Coderre JA,Vicente GH,et al.Boron neutron capture therapy of cancer:current status and future prospects.Clin Cancer Res,2005,11:3987-4002.
  • 2Nakagawa Y,Pooh K,Kobayashi T,et al.Clinical review of the Japanese experience with boron neutron capture therapy and a proposed strategy using epithermal neutron beams.J Neurooncol,2003,62:87-99.
  • 3Diaz AZ.Assessment of the results from the phase Ⅰ / Ⅱ boron neutron capture therapy trials at the Brookhaven national laboratory from a clinician's point of view.J Neurooncol,2003,62:101-109.
  • 4Busse PM,Harling OK,Palmer MR,et al.A critical examination of the results from the Harvard-MIT NCT program phase Ⅰ clinical trial of neutron capture therapy for intracranial disease. J Neurooncol,2003,62:111-121.
  • 5Kankaanranta L, Seppala T, Koivunoro H, et al. L-Boronophenylalanine-mediated boron neutron capture therapy for malignant glioma progressing after external beam radiation therapy:a phase Ⅰ study.Int J Radiati Oncol Biol Phys,2011,80:369-376.
  • 6Kankaanranta L,Seppala T,Koivunoro H,et al.Boron neutron capture therapy in the treatment of locally recurred head-and-neck cancer:final analysis of a phase Ⅰ / Ⅱ trial.Int J Radiat Oncol Biol Phys,2011,In Press.
  • 7Kawabata S,Miyatake SI,Kuroiwa T,et al.Boron neutron capture therapy for newly diagnosed glioblastoma.J Radiat Res,2009,50:51-60.
  • 8Miyatake SI,Kawabata S,Yokoyama K,et al.Survival benefit of boron neutron capture therapy for recurrent malignant gliomas.J Neurooncol,2009,91:199-206.
  • 9Coderre JA,Morris GM. The radiation biology of boron neutroncapture therapy.Radiat Res,1999,151:1-18.
  • 10Nigg DW. Computational dosimetry and treatment planning considerations for neutron capture therapy.J Neuro Oncol,2003,62:75-86.

同被引文献30

  • 1Yamamoto T, Nakai K, Matsumura A. Boron neutron capture therapy for glioblastoma [ J ]. Cancer Lett, 2008,262 ( 2 ) : 143 - 152.
  • 2Cumberlin RL. Clinical research in neutron capture therapy [ J ]. Int J Radiat Oncol Biol Phys, 2002,54(4) :992 -998.
  • 3Miyatake S, Kawabata S, Yokoyama K, et al. Survival benefit of Boron neutron capture therapy for recurrent malignant gliomas [ J ]. J Neuroonco1,2009,91 (2) : 199 - 206.
  • 4Kageji T, Mizobuchi Y, Nagahiro S, et al. Clinical results of boron neutron capture therapy (BNCT) for glioblastoma [ J ]. Appl Radiat Isot,2011,69(12) :1823 - 1825.
  • 5Skold K, Gorlia T, Pellettieri L, et al. Boron neutron capture therapy for newly diagnosed glioblastoma multiforme: an assessment of clinical potential[J]. Br J Radiol,2010,83 (991) :596 - 603.
  • 6Yamamoto T, Matsumura A, Nakai K, et al. Current clinical resuits of the Tsukuba BNCT trial [ J ]. Appl Radiat Isot, 2004,61 (5) :1089 - 1093.
  • 7Aiyama H, Nakai K, Yamamoto T, et al. A clinical trial protocol for second line treatment of malignant brain tumors with BNCT at University of Tsukuba[ J ]. Appl Radiat Isot,2011,69 (12) : 1819 - 1822.
  • 8Barth RF, Coderre JA, Vicente MG, et al. Boron neutron capture therapy of cancer: current status and future prospects [ J ]. Clin Cancer Res ,2005,11 ( 11 ) :3987 - 4002.
  • 9Crossley EL, Issa F, Scarf AM, et al. Synthesis and cellular uptake of boron - rich pyrazolopyrimidines: exploitation of the translocator protein for the efficient delivery of boron into human glioma cells [ J ]. Chem Commun ( Camb ), 2011,47 ( 44 ) : 12179 - 12181.
  • 10Sumitani S, Oishi M, Yaguchi T,et al. Pharmacokinetics of core -polymerized, boron - conjugated micelles designed for boron neutron capture therapy for cancer [ J ]. Biomaterials, 2012,33(13) :3568 -3577.

引证文献2

二级引证文献1

中华放射肿瘤学杂志
2012年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部