前列腺癌根治术后病理分期、Gleason评分与术前血清PSA的相关性分析

Correlation of serum PSA with Gleason score and pathological stage after radical prostatectomy in patients with prostate cancer

目的探讨前列腺癌患者根治术后病理分期、Gleason评分与术前血清PSA的相关性。方法收集香港中文大学附属威尔斯亲王医院泌尿外科2008年1月至2010年9月采用4-臂daVinci S-HD机器人外科手术系统施行前列腺根治性切除术的100例前列腺癌患者的临床资料数据,采用Spearman等级相关分析探讨根治术后病理分期、Gleason评分与术前血清PSA的相关性。结果患者PSA值与Gleason评分呈正相关(r=0.382,P<0.01),PSA值越高,Gleason评分值越高。PSA值与病理分期无明确的相关性(r=-0.073,P>0.05)。结论前列腺癌患者术前血清PSA与根治术后Gleason评分有关,与病理分期无明确的相关性。

Objective To investigate the correlation of serum prostate specific antigen （PSA） with Gleason score and pathological stage after radical prostatectomy in patients with prostate cancer. Methods A survey has been performed on 100 inpatients with prostate cancer who underwent robot-assisted laparoscopic radical prostatectomy （rLRP） using the da Vinci robotic surgical system from Jan 2008 to Sep 2010 in the surgery department, urology division of the Prince of Wales Hospital at The Chinese University of Hong Kong. Spearman rank correlation was applied to evaluate the correlation of serum total PSA with Gleason score and path- ological stage after radical prostatectomy. Results Serum total PSA was significantly positively correlated with Gleason score （ r = 0.382, P 〈 0. 01 ）, but not significantly correlated with pathological stage （ r = - 0. 073, P 〉 0.05）. Conclusion Serum total PSA is correlated with Gleason score but not correlated with pathological stage after radical prostatectomy in patients with prostate cancer.