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Caveolin-1与鼻咽癌细胞侵袭转移能力的相关性研究 被引量：1

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摘要 目的:观察Caveolin-1(CAV-1)基因在鼻咽癌细胞株5-8F和6-10B的表达,初步探讨其与鼻咽癌细胞株侵袭转移能力的关系。方法:(1)荧光定量PCR(quantitative RT-PCR,qRT-PCR)检测CAV-1在鼻咽癌细胞株5-8F、6-10B和永生化鼻咽癌上皮细胞株NP69中的表达情况。(2)用免疫组化检测其在细胞株5-8F和6-10B在组织中的表达情况。结果:(1)qRT-PCR结果显示CAV-1在5-8F细胞株中的表达高于在6-10B中的表达,差异有统计学意义(P=0.014)。(2)免疫组织化学结果CAV-1在5-8F和6-10B组织中也明显差异。结论:CAV-1在5-8F细胞和组织中高表达可能和其高侵袭,高转移能力相关。
作者 冷雷 戚飞飞 任俊奇
机构地区 南方医科大学附属小榄医院 广州市白云区中医院
出处 《实用医学杂志》 CAS 北大核心 2011年第24期4454-4456,共3页 The Journal of Practical Medicine
关键词 鼻咽肿瘤 转移 荧光定量PCR 免疫组织化学
分类号 R739.63 [医药卫生—肿瘤]
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参考文献7

  • 1Liu T, Ding Y, Xie W, et al. An imageable metastatic treatment model of nasopharyngeal carcinoma [J]. Clin Cancer Res, 2007,13 ( 13 ) : 3960-3967.
  • 2Li M, Chen H, Diao L, et al. Caveolin-1 and VEGF-C promote lymph node metastasis in the absence of intratumoral lymphangiogenesis in non-small cell lung cancer [J]. Tumori, 2010, 96 (5) : 734-743.
  • 3Yang G, Addai J, Wheeler T M, et al. Correlative evidence that prostate cancer cell-derived caveolin- 1 mediates angiogenesis [J]. Hum Pathol, 2007,38 ( 11 ) : 1688-1695.
  • 4Kato K, Hida Y, Miyamoto M, et al. Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage [J]. Cancer, 2002, 94(4) :929-933.
  • 5刘惠宁,蔡净亭,林秋华,何可人,余蓉.Caveolin-1与绒毛膜癌侵袭力之间的关系[J].中南大学学报（医学版）,2008,33(4):331-337. 被引量：4
  • 6Du Z M, Hu C F, Shao Q, et al. Upregulation of caveolin-1 and CD147 expression in nasopharyngeal carcinoma enhanced tumor celt migration and correlated with poor prognosis of the patients [ J ]. Cancer Cell Biol, 2009,125 (4) : 832-1841.
  • 7Goetz J G, Minguet S, Navarro-Lerida 1, et al. Biomechanical remodeling of the microenviron-ment by stromal caveolin-I favors tumor invasion and metastasis [J]. Cell, 2011,146( 1 ) : 148-163.

二级参考文献10

  • 1Glenney J R Jr, Zokas L. Noveltyrosine kinase substrates from Rous Sarcoma vires-transformed cell are present in the membrane skekton[ J]. J Cell Biol, 1989, 108 (6) : 2401-2408
  • 2Frank P G, Lisanti M P. caveolin-1 and liver regeneration: role in proliferation and lipogenesis [ J ]. Cell Cycle, 2007, 6(2) : 115-116.
  • 3Torres V A, Tapia J C, Rodriguez D A, et al. caveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivin [ J ] . J Cell Sci, 2006, 119(Pt 9) : 1812-1823.
  • 4Iguchi K, Matsunaga S, Nakano T, et al. Inhibition of caveolin-1 expression by incadronate in PC-3 prostate cells [J]. Anticancer Res, 2006, 26(4B) : 2977-2981.
  • 5Kato K, Hida Y, Miyamoto M, et al. Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage [ J ]. Cancer, 2002, 94(4) : 929-933.
  • 6Kim H A, Kim K H, Lee R A. Expression ofcaveolin-1 is correlated with Akt-1 in colorectal cancer tissues [ J ] . Exp Mol Pathol, 2006, 80(2) : 165-170.
  • 7Hayashi K, Matsuda S, Machida K, et al. Invasion activating caveolin-1 mutation in human scrirhous breast cancers [J]. Cancer Res, 2001, 61(6) : 2361-2364.
  • 8Grummer R, Hohn H P, Mareel M M, et al. Adhesion and invasion of three human choriocarcinoma cell lines into human endometrium in a three-dimensional organ culture system [J]. Placenta, 1994, 15(4) : 411-429.
  • 9Elbashir S M , Lendeckel W, Tusehl T. RNA interference is mediated by 21-and 22-nucleotide RNAs [ J ]. Genes Dev, 2001, 15(2): 188-200.
  • 10Elbashir S M, Harborth J, Lendeckel W, et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells[J]. Nature, 2001, 411 (6836): 494-498.

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实用医学杂志
2011年 第24期

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