血管紧张素Ⅱ受体拮抗剂在高血压合并糖尿病患者中的应用观察

Application of angiotensin Ⅱ receptor antagonist in patients with hypertension and diabetes

目的观察血管紧张素Ⅱ受体拮抗剂对于高血压合并糖尿病的治疗效果。方法选择确诊为高血压合并糖尿病患者62例为治疗组,另选原发高血压患者28例为对照组。观察其治疗前后收缩压(SBP)、舒张压(DBP),空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbAlc),甘油三酯(TG)、低密度脂蛋白胆固醇(LDL)等指标的变化。结果治疗组治疗后SBP、DBP、HbAlc、FPG、2hPG水平较治疗前明显降低,而TG、LDL差异没有统计学意义。对照组除DBP、SBP明显降低外,其他各项生化指标无显著性改变。结论血管紧张素Ⅱ受体拮抗剂具有良好的降压效果,同时可降低2型糖尿病的发病率,在高血压合并糖尿病的治疗中有较好的效果,且副作用较少。

Objective To observe the angiotensin Ⅱ receptor antagonist for the treatment of hypertension and diabetes. Methods Sixty - two hypertensive patients with diabetes were placed in the treatment group and 28 cases of primary hypertension in the control group. The indicators of systolic and diastolic blood pressure, fasting glucose, 2 - hour postprandial blood glucose, glycated hemoglobin, triglycerides and low- density lipoprotein cholesterol before and after treatment were observed. Results After treatment, levels of SBP, DBP, HbAlc, FPG, 2hPG in the treatment group were significantly lower than those before treatment, and TG, LDL level had no significant change. Except for DBP, SBP levels were significantly lower in the control group, and the other biochemical indicators had no significant change. Conclusion While reducing the incidence of type 2 diabetes, the angiotensin receptor antagonist has good antihypertensive effect and low rate, and it has relatively good results and fewer side effects in the treatment of hypertension and diabetes.