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他克莫司和雷帕霉素对肝癌肝移植患者Foxp3^+ Treg产生的影响 被引量：2

The Effectiveness of Foxp3+ Treg on Carcinoma of Liver Transplantation in Tacrolimus and Rapamycin
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摘要 目的探讨他克莫司和雷帕霉素对肝癌肝移植患者Foxp3+Treg产生的影响。方法挑选符合Milan标准肝癌肝移植患者,按随机数法分为Rapa组和Tac组,每组20例,第2～12月间每月抽取外周血应用流式细胞术(FCM)检测Foxp3+T细胞及研究中间进行一次肝穿刺活检证实排斥反应。结果 FCM检测外周血Foxp3+T细胞阳性率比较雷帕霉素组明显高于他克莫司组,移植肝穿刺活检亦证实雷帕霉素组排斥反应较他克莫司组并未增加。结论雷帕霉素在肝癌肝移植中排斥反应较他克莫司并未增加,甚至有更好的免疫耐受结果。 Objective To study the effectiveness of Foxp3＋ Treg on Tacmlimus and Rapamycin in patient after carcinoma of liver transplantation. Methods Forty patients were randomLy assigned into the Tacrolimus group（n=20） and Rapamycin group（n=20）. The patients were detected Foxp3 Treg cell by FCM and hepatic tissue biopsy. Results In Rapamyein group Foxp3＋ Treg were significantly increased. Conclusion It is suggested that Rapamycin has protective effect on patient after carcinoma of liver transplantation.
作者 陈国勇 孙建军 谢寒冰 陈建斌 汤高枫 谢占涛 赵会博 季节 蒋进发
机构地区 郑州人民医院
出处 《中国医药指南》 2011年第36期26-27,共2页 Guide of China Medicine
关键词 雷帕霉素 他克莫司 肝癌肝移植 FOXP3 TREG细胞 Sirolimus Tacrolimus Carcinoma of liver transplantation Foxp3 Treg cell
分类号 R735.7 [医药卫生—肿瘤]
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共引文献14

同被引文献14

  • 1崔福德.药剂学[M] .7版.北京:人民卫生出版社,2011:197-198.
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  • 4Flechner SM, Gurkan A, Hartmann A, et al. A randomized, open-label study of sirolimus versus cyclosporine in primary de novo renal allograft recipients[J]. Transplantation, 2013, 95(10): 1233-1241.
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  • 9陈悦.HPLC法测定他克莫司的含量及有关物质[J].药物分析杂志,2008,28(2):309-313. 被引量：11
  • 10魏静,徐国旭,龚铠,盛敏杰,林安娟.雷帕霉素眼膏的制备及其含量测定[J].中国现代医药杂志,2010,12(6):11-14. 被引量：7

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中国医药指南
2011年 第36期

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