人工流产4种镇痛方法的临床效果观察

Study on Analgesic Effect by 4 Different Compatibility of Drugs During Painless Artificial Abortion

目的探讨人工流产镇痛方法的最佳药物配伍组合。方法选择ASAⅠ级人工流产者400例,随机分为四组,每组100例。A组:芬太尼50μg、安定10 mg;B组:芬太尼50μg、阿托品0.2 mg和丙泊酚2.0～2.5 mg/kg;C组:芬太尼20μg、阿托品0.2 mg和丙泊酚2.5 mg/kg;D组:芬太尼20μg、阿托品0.2 mg、安定5 mg和丙泊酚2.0～2.5 mg/kg。评价镇痛效果、循环、呼吸系统变化及不良反应。结果 B组镇痛效果满意,术后恢复良好,与其它3组比较有显著性差异(P<0.05),而循环、呼吸系统变化及不良反应4组间比较无统计学意义(P>0.05)。结论芬太尼50μg、阿托品0.2 mg、丙泊酚2.0～2.5 mg/kg联合静脉麻醉镇痛效果满意,不良反应小,是一种较理想的人工流产镇痛方法。

Objective To study the best clinical effect on termination of early pregnancy by giving the different compatibility of drugs during painless artificial abortion. Methods 400 women with ASA class I who asked for painless artificial abortion were divided randomLy into four groups： A group（100 cases） were intravenous injected with fentanyl 50lag, and diazepam 10rag before operation, B group（100 cases） with fentanyl 50lag, atropine 0.2mg and propofol 2.0-2.5mg/kg before operation,C group（100 cases） with fentanyl 20μg, atropine 0.2mg and propofol, D group（100 cases） with fentanyl 20μg, diazepam 5rag, atropine 0.2mg and propofol 2.0-2.5mg/kg before operation. The analgesic effect, respiratory and circulatory system complications were observed in four groups.Results There was the best analgesic effect in B group, the difference between B and the others was significant（P〈0.05）, but respiratory and circulatory system complications had no significant difference among four groups（P〉0.05）. Conclusions The analgesic effect by fentanyl 50μg, atropine 0.2mg and propofol 2.0-2.5mg/kg is satisfied for artificial abortion. It,s one of better ways for the artificial abortion analgesic.