阿立哌唑与氯丙嗪治疗慢性精神分裂症的对照研究

Control study of Aripiprazole and Chlorpromazine in the treatment of chronic schizophrenia

目的:比较阿立哌唑与氯丙嗪对慢性精神分裂症的疗效。方法:将慢性精神分裂症60例随机分成两组,分别服用阿立哌唑和氯丙嗪,观察疗程12周。用阳性和阴性症状量表(PANSS)及副反应量表(TESS)评定疗效和不良反应。结果:阿立哌唑组与氯丙嗪组总有效率分别为83.3%和80.0%。治疗前后阴性量表分两组间差值比较差异有显著意义(P<0.05)。治疗期间未发现严重不良反应。结论:阿立哌唑对慢性精神分裂症疗效与氯丙嗪相当,但对阴性症状疗效明显优于氯丙嗪。

Objective：To caropare curative effect of Aripiprasole and Chlorpromazine in the treatment of chronic schizophrenia, Methods：60 patients with chronic schizophrenia were randomly divided into two groups,treatment 12 weeks. The curative effect and adverse reactions were assessed with PANSS and TESS. Results：Aripiprazole ~oup and ehlorpremazine group total effective rate was 83.3% ,80.0%. Negative scale points before and after treatment between the two groups was the difference ,differences were significant（ P 〈 0.05 ）. During treatment not found serious reactions. Condutfion： Aripiprazole is as effective as Chlorproroasine in the treatment of chronic schizophrenia, but to negative symptoms was better than ehlm＇proroazine.