摘要
目的探讨新疆维吾尔族高尿酸血症患者血清白介素-6水平的变化及相关影响因素。方法对211例高尿酸血症患者(高尿酸血症组)检测一般身体指标、生化指标及血清白介素-6,并与同期住院的无高尿酸血症及痛风、无血缘关系其他疾病患者200例(对照组)进行分析比较。结果高尿酸血症组体质指数、甘油三酯、白介素-6水平明显高于对照组,血清白介素-6水平与尿酸及高密度脂蛋白呈正相关,多元线性逐步回归分析显示尿酸及高密度脂蛋白为其独立相关因素。结论维吾尔族高尿酸血症与肥胖、血脂异常等代谢综合征存在共同的发病基础,血清白介素-6水平与高尿酸血症具有相关性。
Objective To analyze IL-6 levels and related biochemical factors in patients with hyperuricemia in Xinjiang Uygur populations.Methods The 411 samples were collected from January to July 2008 in the affiliated Chinese medicine hospital to collect the venous blood on an empty stomach, measured and calculated the indexes including height、body weigh、waist circumference（WC）、hip circumference（HC）、waist-to-height ratio（WHTR）、waist-to-hipratio（WHR）、BMI、blood pressure and analyze for SUA、TG、TC、HDL-C、LDL-C、VLDL-C, to use ELISA to detect the serum IL-6. Results The IL-6 levels in hyperuricemia group was higher than that in control group. The multiple logistic regression showed the IL-6 levels was positively related to SUA and HLDL-C. Conclusions There may be the same foundation among hyperuricemia、obesity and metabolic disorder. The IL-6 level significantly increased in Uygur patients with hyperuricemia , which may play a role in the pathogenesis of hyperuricemia.
出处
《新疆医科大学学报》
CAS
2011年第12期1335-1338,共4页
Journal of Xinjiang Medical University
基金
国家自然科学基金资助项目(编号:30760221)
