乌鲁木齐某医院2008—2009年127例药品不良反应报告分析

Analysis of 127 cases of adverse drug reaction reports in 2008-2009 from a hospital in Urumqi

目的了解乌鲁木齐市中医医院药品不良反应(ADR)的发生特点及引发ADR的相关因素,为临床合理用药提供参考。方法对乌鲁木齐市中医医院2008-2009年收集的127例药品不良反应报告进行回顾性分析。结果 127例ADR报告中,以静脉滴注给药引发的ADR最多,占总例数的92.13%(117/127),其次是抗菌药物引起的ADR,占总例数的70.87%(90/127);引起ADR比例较高的抗菌药物为喹诺酮类、硝咪唑类、林可霉素类。ADR表现以皮肤及附件损伤最为常见,占总例数的60.63%(77/127)。结论给药途径、药物种类等因素均会影响ADR的发生,临床应重视药品不良反应的报告及检测,减少注射剂的使用,合理使用抗菌药物,以减少或避免ADR的发生。

Objective To know the characteristics of the adverse drug reaction （ADR） occurred in Urumqi TCM Hospital, and to find out the related factors caused by ADR so as to promote clinical rational drug use. Methods Retrospective analysis of 127 cases of ADR reports during the period of 2008-2009 in Urumqi TCM Hospital. Results In 127cases of ADR reports, the most incidence of ADR caused by intravenous drip, account for the total number 92.13% （117cases）. Secondly, the incidence of ADR caused by antibacterial drugs, account for the total number 70.87% （90 cases）. The most incidence of ADR was caused by Quinolones, Nitroimidazoles, Lincomycin. The most common symptom was the injury of skin and accessories, account for 60.36% （77cases）.Conclusion The influence factors contain administration way, drug types. The detections of ADR should be attached importance to clinic. Decreasing the use of injections and antibiotics could reduce or avoid the incidence of ADR.