子宫切除术后绝经综合征发生情况的临床观察

The clinical observation on the incidence of menopausal syndrome after hysterectomy

目的探讨子宫切除术后2年患者绝经综合征症状出现的情况及卵巢功能的变化。方法选择新疆医科大学附属中医医院2008年5月-2009年2月因子宫良性病变行子宫切除术保留双侧卵巢的患者37例作为观察组。同年龄段因阴道炎于门诊就诊的女性30例作为对照组,以电话随访和问卷调查的形式了解其绝经综合征发病情况,并检测两组患者性腺激素雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)水平。结果子宫切除术后2年观察组绝经综合征出现率为32.43%,对照组为10.0%,观察组中有重度忧郁多疑6例,烦躁易怒、失眠、乏力各5例,明显多于对照组,两组相比差异有统计学意义(P均<0.05),两组E2、FSH、LH水平相比差异有统计学意义(P<0.05)。结论子宫切除术后2年女性较同龄保有子宫的女性提前出现绝经综合征症状,症状中主观精神神经系统症状较为明显,有卵巢功能提早减退的情况。

Objective To investigate the characteristic of patients who take hysterectomy in 2 years with menopausal syndrome symptoms and changes in ovarian function.Methods We collect 37 patients from the department of gynecology in the fourth affiliated hospital of Xinjiang Medical University who due to benign uterine hysterectomy with bilateral ovarian retained in our hospital in May 2008-2009 February as the study group.30 cases of female with the same age because of vaginitis in outpatients were taken as the observation group.They were followed up by telephone survey form and to understand the menopausal syndrome,and to test two groups of gonadal hormone levels.Results After two years of menopause syndrome study group there was 32.43%,the control group was 10.0%,the observation group had 6 cases of severe depression,paranoia,irritability,insomnia,all 5 patients in the control group was 0 cases,the two groups was statistically significant difference（P0.05）,the gonadal hormones of two group： E2,FSH,LH statistically significant different（P0.05）.Conclusion 2 years after the patients undergone hysterectomy than women without the operation early age appears to syndrome symptoms,subjective symptoms of neuropsychiatric symptoms in the more obvious,there is an early decline of ovarian function in the situation.