2194例男性泌尿生殖道支原体检测及药敏分析

Detection and drug sensitivity assay of Mycoplasma in 2194 cases of male genitourinary infection

目的研究男性泌尿生殖系统炎症患者解脲脲原体(Uu)和人型支原体(Mh)感染及对抗菌药物耐药情况,以了解本地区男性支原体的感染流行状况并指导临床合理选择使用抗菌药物。方法采用支原体鉴定药敏试剂盒,对男性生殖道感染者进行支原体培养及药敏试验。结果 2 194份标本中检出支原体636例,阳性率为28.96%,其中解脲脲原体阳性率为22.59%,人型支原体阳性率为0.96%,解脲脲原体和人型支原体混合感染阳性率为5.42%。支原体对抗菌药物药敏结果显示,抗菌活性较高的是多西环素、普拉霉素、四环素和交沙霉素。结论Uu是男性泌尿生殖系统支原体感染的主要病原体。临床治疗支原体感染时应尽量根据药敏结果选择敏感药物。普拉霉素、多西环素、四环素和交沙霉素可作为本地区非淋菌尿道炎经验用药的首选药物,避免使用喹诺酮类药物。

Objective To investigate the Uu and Mh infection of male urogenital system and its drug-resistance, and provide guidance for reasonable choice of the clinical medicine for preventing and treating male urogenital infection. Method Mycoplasma and their drag sensitivity were detected by culture method and analyze. Result In the 2194 cases, 496 （22.59%） cases were Uu positive ; 21 （0.96%） cases were Mh positive. There were 119 （5.42%） cases of mixed infection. The drug-sensitivity test showed that doxycycline, pristinamycin, tetracyclines and josamycin had preferable antimicrobial activities. Conclusion The major Mycoplasma inflection is Uu. Selection of antibiotics should be based on the result of clinical drug sensitivity test. Pristinamyein, doxycyeline, tetracyclines and josamycin can be used as the preferred choice in NGU treatment, and use of quinolones should be avoided in our area.