鼻康喷雾剂的抗炎实验研究

Experimental study on the anti-inflammatory effect of Bikang Spray on rats

目的观察鼻康喷雾剂对小鼠实验性炎症的影响。方法分别采用二甲苯致小鼠耳廓肿胀模型、醋酸致小鼠腹腔毛细血管通透性增高模型及角叉菜胶致大鼠足跖肿胀模型,观察鼻康喷雾剂的抗炎作用。结果鼻康喷雾剂能降低小鼠腹腔毛细血管通透性,抑制二甲苯所致小鼠耳廓肿胀及角叉菜胶所致大鼠足跖肿胀程度,其抗炎作用显示一定的浓度依赖性特点。结论鼻康喷雾剂对小鼠实验性炎症及毛细血管通透性具有一定的抑制效应。

Objective To investigate the anti-inflammatory effect of Bikang Spray on rats based on an experimental study. Methods Experflnents were carded out on rat models with anricle tumefaction induced by xylene, increased abdominal blood capillary permeability induced by acetic acid, and to rat feet swelling induced by diagonal fork dish glue respectively to observe the anti-inflammatory effects of Bikang Spray these inflammatory changes. Results Following the use of Bikang Spray, reduced significantly were the increased permeability of the abdominal capillary, the degrees of auricle edema, and the severity of hind paw swelling among rat models. Such an anti-inflammatory activity of Bikang Spray showed a tendency of concentration dependence at some level Condusions Bikang Spray can decrease the capillary permeability and inhibit the inflammatory exudation induced experimentally.