中山市27062例体检人群EB病毒感染状况的临床调查研究

Clinical epidemiological investigation on EBV infection status in the general population in Zhongshan City

目的对鼻咽癌高发区广东省中山市普通人群EB病毒感染状况进行临床流行病学调查。方法收集中山市中医院保健中心2007年1月-2008年12月单位集体体检血样27062例，采用酶联免疫（ELISA）法检验血清EBV4fH关抗体，分析不同性别、不同年龄段EB病毒感染率及不同年龄段EB病毒感染的相对危险度。结果在检测到人群中，EB病毒感染率为1．09％，其中男性感染率1．33％，女性感染率0．73％；x2=21．8522，P〈0．01。50-59岁、60～69岁年龄段EB病毒感染率较20-29岁、30-39岁、40-49岁年龄段感染率明显升高（P〈0．05）。结论在鼻咽癌高发区中山市，普通人群EB病毒感染率为1．09％，男性较女性更容易发生感染；中老年感染率较高，应加强该年龄段EB病毒感染者的追踪观察。

Objective To investigate the EB virus （EBV） infection status in the general population of Zhongshan City, Guangdong province, where with a very higher incidence of nasopharyngeal carcinoma （NPC）, based on a clinical epidemiological study. Method Investigated in this study were 27 062 local people for health care examination in our Hospital from January 2007 to December 2008, with their ill history recorded and serum samples collected for determination of EBV-associated antibodies assayed by the procedures of enzymelabeled immunosorbent assay （ELISA）. Then, an analysis was made on the infecting rates of EBV among different gender and different populations at various age subgroups, with a special focus on the relative risk ratio of EBV infection rate in a special age subgroup. Results In this group of studied population, the total EBV infection rate was 1.09%, with such a rate being 1.33% in male and 0.73% in female subgroups （x2=21.8522,P〈0.01）. People at the two subgroups of age from 50 to 59 and 60 to 69 years old showed that the EBV infection rates were significantly higher than those among other subgroups of age from 20 to 29, 30 to 39, and 40 to 49 years old respectively, with statistical significance among them （P〈0.05）, suggesting that the middle-aged and older people having a higher risk of EBV infection. Conclusions EBV infection rate is 1.09% in the general population in Zhongshan City, where the incidence of NPC is much higher, with a much increased risk of EBV infection in male than in female. It is also true for a much higher risk of EBV infection among the middle-aged and older persons （50 to 69-year-old） in the general population. So, intensive health care should be given to the people at these subgroups of age regarding the prevention and treatment of EBV infection.