高铜日粮对生长猪中脑和下丘脑中儿茶酚胺类含量的影响

Effect of high dietary copper on the catecholamines in the hypothalamus and midbrain of growing pigs

选用断乳仔猪45头,随机分为3组,每组5个重复,每个重复3头,采用完全随机化设计进行生长试验,研究了不同添加水平(5、125、250mg/kg)的硫酸铜日粮对猪下丘脑及中脑儿茶酚胺类物质分泌的影响。结果,日粮中添加125mg/kg(P<0.01)、250mg/kg(P<0.05)硫酸铜均显著提高了中脑、下丘脑多巴胺含量,但是随着铜水平的提高,多巴胺含量呈下降趋势;中脑黑质去甲肾上腺素浓度在试验组与对照组之间有显著差异,并且随着铜浓度的提高有升高趋势。据此推断,高剂量铜可能通过调节中枢儿茶酚胺代谢,促进生长激素的分泌进而促进动物生长。

The experiment was conducted to examine effect of dietary copper supplementation on cate- cholamines secretion in the hypothalamus and midbrain of growing pigs. Forty-five crossbred pigs were randomly assigned to three groups of 15 pigs with each comprising 5 replicates of 3 animals. Pigs were allocated to diets that contained 5 （as control）, 125 and 250 mg/kg sulphate copper. In result, the concentration of catecholamines was higher in pigs that were fed diets with 125（P%0.01）and 250 mg/kg sulphate copper（P 〈0.05） ,respectively,than that in pigs fed with 5 mg/kg copper. However, the catecholamines concentration showed the trends of decreasing according to the increasing of the level of copper. The concentration of noradrenalin was higher in the groups fed diets with 125 （P〈0.05）and 250 mg/kg sulphate copper（P〈 0.01）. Furthermore, with the increasing of copper concentration, the noradrenalin concentration was increased. The results indicated that high dietary copper may promote the secretion of growth hormone to grow by regulating the metabolism of catecholamines.