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副黏病毒膜融合机制的研究进展

Research advance in the mechanism of paramyxovirus membrane fusion
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摘要 主要从副黏病毒膜融合的关键蛋白——附着蛋白和融合蛋白的结构与功能、附着蛋白的受体及其作用位点等方面论述了副黏病毒的膜融合机制,并讨论了基于不同附着蛋白受体的附着蛋白和融合蛋白相互作用的差异,以阐明基于不同附着蛋白受体膜融合的不同机制,并为进一步研究病毒入侵靶细胞的机理和该病毒的防治策略提供思路。 Two paramyxovirus glycoproteins,the attachment protein and the fusion（F） protein,are key to the membrane fusion process.The structure and function of these two proteins,receptors and function sites of attachment proteins are discussed in this paper to review the mechanisms of paramyxovirus membrane fusion.And the mechanisims that are based on different receptors are also summarized by illustrating the different interaction between the two proteins.This preview provides some ideas for further study of virus invasion mechanism and control strategies.
作者 王帅 骆学农 窦永喜 张海瑞 才学鹏
机构地区 中国农业科学院兰州兽医研究所家畜病原微生物国家重点实验室 山东亚太中慧集团
出处 《中国兽医科学》 CAS CSCD 北大核心 2011年第12期1308-1313,共6页 Chinese Veterinary Science
基金 公益性农业行业研究专项(20103008) 甘肃省农业生物技术研究与应用开发项目(GNSW-2010-08)
关键词 副黏病毒 附着蛋白 融合蛋白 膜融合机制 paramyxovirus attachment protein fusion protein mechanism of membrane fusion
分类号 S852.659.5 [农业科学—基础兽医学]
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参考文献49

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中国兽医科学
2011年 第12期

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