白介素在溃疡性结肠炎发病机制中的研究进展

Progress in understanding the role of interleukins in the pathogenesis of ulcerative colitis

溃疡性结肠炎(ulcerative colitis,UC)是一种慢性、非特异性炎症性肠病.UC活动性的评估结果可指导临床制订治疗方案.因此寻找有足够的特异性和灵敏度并易于监测UC病情程度的标志物具有重要的临床意义.近些年来随着UC发病机制研究的日益深入,发现白介素(interleukin,IL)在UC发生、发展过程中存在表达改变,提示IL可以作为监测UC病情变化的检测指标,成为UC诊疗的新热点.本文对IL在溃疡性结肠炎发病及病理变化中的作用机制进行综述.

Ulcerative colitis （UC） is a chronic, nonspecific inflammatory bowel disease. The assessment of UC reactiveness can be used to guide clinical treatment. Therefore, it is of important significance to find markers which have sufficient specificity and sensitivity for ease of monitoring UC. In recent years, a intensive study of the relation between interleukins （ILs） and the pathogenesis of UC has revealed changes in the secretion levels of ILs in the progression of UC, which suggests that ILs can be used as markers for monitoring the activity of UC to guide diagnosis and treatment. This paper is a review on the mechanism of action of ILs in the pathogenesis of UC.