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微管相关Tau蛋白mRNA在胃癌中表达的意义 被引量：2

Expression of Tau mRNA in gastric carcinoma
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摘要 目的探讨Tau mRNA在胃癌组织中表达的临床意义。方法采用逆转录-聚合酶链反应方法检测正常胃组织与胃癌组织中Tau mRNA的表达。结果 Tau mRNA在胃癌组织中的表达高于在正常胃组织中的表达(P<0.05),并且高中分化胃癌组织Tau mRNA的表达低于低分化胃癌组织,无淋巴结转移胃癌组织Tau mRNA的表达低于有淋巴结转移胃癌组织且差异有统计学意义(P<0.05),TNM分期Ⅲ+IV期Tau mRNA的相对含量明显高于Ⅰ+Ⅱ期(P<0.05),Tau mRNA含量在不同年龄、性别、病变长度中差异无统计学意义(P>0.05)。结论胃癌组织中Tau mRNA表达水平的升高与胃癌的分化程度及转移有密切的关系。 Objective To elucidate the features of Tau mRNA expression in normal gastric tissue and gastric carcinoma tissue. Methods The expression of Tau mRNA was detected by RT-PCR in normal and carcinomatous gastric tissue. Results The expressing quantity of Tau mRNA was significantly higher in gastric carcinoma tissue than that in normal gastric tissue（P 〈 0.05 ）. The expression of Tau mRNA in well differentiated and moderately differentiated was lower than that in poorly differentiated gastric carcinoma ,the expression of Tau mRNA in gastric carcinoma without lymph node metastasis was lower than that in gastric carcinoma with lymph node metastasis, the expression of Tau mRNA of TNM stage m and IV was significantly higher than that of TNM stage I and U （P 〈 0.05）,Correlations were not found between Tau mRNA and every other characteristics of gastric carcinoma such as age,gender,length of tumor（P 〈 0.05）. Conclusion The higher levels of Tau mRNA of gastric carcinoma was closely related to tumor differentiation degree and metastasis.
作者 张德利 徐贝贝 李春辉
机构地区 承德医学院附属医院病理科
出处 《中国医药科学》 2011年第24期20-22,共3页 China Medicine And Pharmacy
关键词 胃 胃癌 TAU MRNA RT-PCR Gastric tissue Gastric carcinoma tissue Tau mRNA RT-PCR
分类号 R735.1 [医药卫生—肿瘤]
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参考文献11

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共引文献7

同被引文献39

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引证文献2

二级引证文献5

中国医药科学
2011年 第24期

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