大黄蛰虫丸治疗晚期血吸虫病临床疗效

Therapeutic effect of Dahuangzhechong pills on advanced schistosomiasis

目的观察大黄蛰虫丸治疗晚期血吸虫病的疗效及安全性。方法确诊的62例晚期血吸虫病患者随机分为治疗组和对照组2组,每组31例,分别采用大黄蛰虫丸和常规治疗,疗程均为52周,观察治疗前后患者肝功能、肝纤维化指标、肝脏B超影像学的变化。结果大黄蛰虫丸治疗组患者治疗52周后丙氨酸氨基转移酶、总胆红素、肝纤维化指标及B超门静脉内径、门静脉血流量均较对照组有明显改善,差异均有统计学意义(P均<0.05)。大黄蛰虫丸治疗组患者治疗过程中未出现严重不良反应。结论大黄蛰虫丸治疗晚期血吸虫病安全有效。

Objective To evaluate the therapeutic effect and safety of Dahuangzhechong pills on advanced schistosomiasis. Methods Sixty-two patients with advanced schistosomiasis were divided randomly into two groups, a treatment group and a control group, and treated with Dahuangzhechong pills and routine therapy, respectively. The course of treatment was 52 weeks in the two groups. Before and after the 52-week treatment, the indexes of liver function and hepatic fibrosis, prothrombin time （PT）, Child-Pugh scores and changes of B-type ultrasonic images were detected for all the patients. Results There were significant differences in the levels of alanine aminotransferase （ALT） and total bilirubin （TBIL）, the indexes of hepatic fibrosis, portal venous inside diameters and portal venous flow between the two groups after 52 weeks treatment （P〈0.05）. In addition, there were no obvious adverse effects during the treatment in the patients of the Dahuangzhechong pill group. Conclusion Dahuangzhechong pill treatment is a safe and effective therapy for the patients with advanced schistosomiasis.