PER2在食管癌及癌旁组织中的差异性表达及意义

Differentially expression and clinical significance of PER2 in esophageal carcinoma and adjacent tissue

目的:探讨节律基因Per2表达的PER2蛋白在食管癌中的表达及其与临床意义。方法:应用免疫组织化学方法检测40例食管癌组织,40例癌旁组织中PER2的表达。结果:40例食管癌旁组织标本100%呈现为PER2阳性表达,表达强度++～+++,而40例食管癌组织中24例呈阴性表达,16例PER2呈弱阳性表达,表达强度+～++。两组表达的差异性具有统计学意义,P<0.05。结论:Per2基因可能作为一种抑癌基因影响肿瘤的发生发展。

Objective： To investigate the expression of PER2 in esophageal carcinoma and adjacent tissue to analyze its clinical significance.Methods： The expressions of PER2 in 40 cases of esophageal carcinoma and 40 cases of adjacent tissue were measured by imunohistochemistry.Results： All the 40 specimens in adjacent tissue of esophagus carcinoma appeared PER2 positive expression（the intensity of expression： ＋＋~＋＋＋）,while 24 specimens in esophagus carcinoma tissue present PER2 negative expression and 16 cases weakly positive expression（the intensity of expression：＋~＋＋）.There is significant difference between two groups（P0.05）.Conclusion： Per2 perhaps influence the progression of esophagus cancer as a tumor suppressor gene.