奥氮平联合氯氮平治疗难治性精神分裂症患者的疗效观察

The effect of olanzapine combined with clozapine in the treatment of refractory schizophrenia

目的:观察奥氮平联合氯氮平治疗难治性精神分裂症的疗效和不良反应。方法:50例难治性精神分裂症患者随机分为合用药组和单用药组各25例。合用药组给予奥氮平合并小剂量氯氮平治疗,单用药组仅给予奥氮平治疗。疗程12周。采用阳性与阴性症状量表(PANSS)及治疗中出现的症状量表(TESS)于治疗前及治疗4、8、12周分别评定疗效和不良反应。结果:治疗后两组PANSS总分、阳性症状及阴性症状分均较治疗前明显降低(P<0.05或P<0.01),以合用药组显著低于单用药组(P<0.05)。两组不良反应比较差异无统计学意义(P>0.05)。结论:奥氮平联合氯氮平治疗难治性精神分裂症疗效好,不良反应少且依从性好。

Objective：To investigate the efficacy and adverse reactions of olanzapine combined with clozapine in the treatment of refractory schizophrenia. Method：The 50 patients of refractory schizophrenia were randomly divided into combined drug group and single-use drug group,25 cases each.Combination group were given a small dose of olanzapine combined with clozapine,single group were given olanzapine,treatment lasted 12 weeks.Positive and negative syndrome scale（PANSS） and treatment emergent symptom scale（TESS） were used to evaluate the efficacy and adverse drug reactions,before treatment and 4,8,12 weeks after starting treatment were assessed respectively. Results：The scores of total PANSS and positive and negative factor scores were decreased in both groups（P0.01 or P0.05） ,but they decreased more quickly in the combined group（P0.05） .Adverse reactions difference between the two groups was not significant（P0.05） . Conclusion：Olanzapine combined with clozapine treatment of refractory schizophrenia,can significantly improve the positive and negative symptoms,better efficacy,fewer side effects and better compliance.