卡维地洛治疗慢性充血性心力衰竭临床观察

Clinical Observation of Carvedilol on Chronic Congestive Heart Failure

目的:观察卡维地洛在慢性充血性心力衰竭(CHF)治疗中的疗效。方法:将63例CHF病人随机分为对照组和观察组,对照组给予基础治疗,包括利尿剂、ACEI或ARB、强心药、硝酸酯类等;观察组给予基础治疗外加用卡维地洛,起始剂量为5 mg,每天1次口服,2周后剂量加倍维持,12个月后对患者心功能、心率、左室射血分数(LVEF)、左室舒张末内径(LVEDD)、6 min步行试验结果进行比较。结果:观察组患者的各项观察指标与对照组相比,差异均有统计学意义(P<0.05)。结论:CHF患者在应用利尿剂、ACEI和强心治疗的基础上加用卡维地洛可更好地改善患者的心功能,降低左室舒张末内径,提高射血分数,改善患者的生活质量。

Objective： To observe the curative effects of carvedilol on chronic congestive heart failure（CHF）.Methods： Sixty three patients with CHF were randomly divided into control group and treatment group.The control group was given basic treatment,including diuretics,ACEI or ARB,cardiotonic drug,nitrate and so on.Besides basic treatment,the treatment group was also given carvedilol,with an initial dose of 5 mg,one time a day orally.After 2 weeks,the dose was doubled.After 12 months,the heart function,heart rate,left ventricular ejection fraction（LVEF）,left ventricular end diastolic diameter（LVEDD）,and 6 minute walk test were measured and compared between two groups.Results： There were significant differences in every observation index between two groups.Conclusion： For cases with CHF,on the basis of diuretics,ACEI and cardiotonic drug treatment,carvedilol can improve the heart function,reduce LVEDD,increase LVEF,and improve the life quality of patients.