C-反应蛋白在鉴别诊断系统性红斑狼疮患者感染的临床意义

Clinical Significance of C-reactive Protein in Systemic Lupus Erythematosus

目的:探讨SLE患者发病的临床特征,为开展有效救治,以改善预后、提高生活质量提供参考。方法:收集2009年6月至2011年6月住院治疗并进行血清CRP检测的SLE患者共90例,分为感染组与非感染组,并比较分析CRP浓度。结果:SLE患者感染组CRP浓度9.8±3.5 mg/L明显高于非感染组6.0±4.6 mg/L,两者差异有统计学意义(P<0.05);而非感染组中狼疮活动组与非活动组CRP浓度差异无统计学意义(P>0.05)。结论:CRP可以作为一个鉴别SLE患者感染的敏感实用性指标,若CRP>8 mg/L应首先考虑合并感染。

Objective： To investigate the clinical features of systemic lupus erythematosus（SLE）,and to provide references for developing effective treatment,as well as improving prognosis and life quality.Methods： Ninety patients with SLE were recruited,and their serum levels of C-reactive protein（CRP） were detected from June of 2009 to June of 2011.The patients were divided into infection group and non-infection group,and CRP levels were compared between two groups.Results： The CRP levels in infection group（9.8±3.5 mg/L） were significantly higher than in non-infection group（6.0±4.6 mg/L）.But in non-infection group,there were no significant differences in CRP levels between the active and inactive lupus.Conclusion： CRP can be used as a sensitive and useful indicator for infection in patients with SLE.If the level of CRP is more than 8 mg/L,co-infection should be considered.