胃脘痛血瘀证与血栓素、前列腺素、血液流变学及幽门螺杆菌的相关性研究

The Correlative Study of Blood Stasis Syndrome in Stomachalgia Patients and Thromboxane Prostaglandin and Helicobacter Pylori

目的 :研究胃脘痛血瘀证与血栓素 (TXB2 )、前列腺素 (6 - keto- PGF1α)、血液流变学及幽门螺杆菌 (HP)感染的关系。方法 :观察胃脘痛血瘀证及脾虚证患者各 31例 ,采用放射免疫法检测 TXB2 和 6 - keto- PGF1α,尿素酶法检测 HP感染 ,樵板式粘度计测定血液流变学。结果 :胃脘痛血瘀证 TXB2 、TXB2 / 6 - keto- PGF1α水平明显高于脾虚证组和正常对照组 ,脾虚证组明显高于正常对照组 ;两证 PGF1 a水平均明显低于正常对照组 ,但两者之间无显著性差异。不同病种血瘀证和脾虚证比较也得出了类似的结果 ,并发现 TXB2 升高与血液流变相关。 HP检测发现 ,胃脘痛血瘀证组 HP感染率明显高于脾虚证组。结论 :TXB2 、TXB2 / 6 - keto- PGF1 a升高可作为胃脘痛血瘀证一项辅助诊断指标。

Objective:To study the correlation of blood stasis syndrome (BSS) with thromboxane(TXB 2) and prostaglandin F lα (PGF lα ) in stomachalgia patients. Methods:62 stomachalgia patients were divided into two groups,BSS group(31 cases)and spleen deficiency syndrome(DSS) group (31 cases).Among them,TXB 2,PGF lα ,TXB 2/PGF lα ,H. Pylori of blood were detected by radioimmunoassay (RIA) of speed urease.Results:The level of TXB 2,TXB 2/PGF lα in BSS group were markedly higher than that in DSS group and normal group (BSS group>DSS group>normal group).But PGF lα level of BSS group and DSS group were obviously lower than that of the normal group.There is not significant difference between BSS group and DSS group and H. Pylori infectious rate of BSS group was obviously higher than that of DSS group.Conclusion:Increase of TXB 2,TXB 2/PGF lα can be a instrumental diagnostic indication on BSS of stomahalgia H. pylori infection.