血浆脑钠肽对老年慢性心力衰竭的诊断价值及预后评估

Plasma BNP in Chronic Heart Failure Diagnosis and Prognostic Assessment

目的探讨血浆脑钠肽(BNP)水平对老年慢性心力衰竭(CHF)的诊断价值及预后评估。方法依据美国弗明汉心脏病研究中心Framingham危险评分诊断48例心力衰竭患者,按美国纽约心脏病学会心功能分级(NY-HA)、左室射血分数(LVEF)分组,采用免疫荧光法检测血浆BNP水平。结果 BNP>400 pg/ml可作为诊断CHF的界值,BNP水平随着NYHA分级增高而升高,差异有统计学意义(P<0.01)。结论 BNP水平可作为临床诊断CHF的指标并可评估患者预后。

Objective To investigate the plasma brain natriuretic peptide （BNP） levels in heart failure （CHF） diagnosis and prognosis assessment. Methods Use Framingham criteria to diagnose the disease of heart failure; NYHA to grade the disease ; LVEF to group the disease; to detect BNP level. Results 400 pg/ml of BNP level can be used as the lowest boundary value to diagnose CHF; the higher of NYHA, the higher of BNP level, the difference was significant （P 〈 0. 01 ）. Conclusion BNP level can be used as diagnosis criteria for CHF and prognostic assessment.