DYX1C1基因1249G>T多态性与阅读障碍易感性关系的Meta分析

A Meta-analysis on Association between DYX1C1 1249G>T Polymorphism and Dyslexia Susceptibility

目的综合评价DYX1C1基因1249G>T多态性与阅读障碍易感性之间的关系。方法全面检索相关文献,收集2011年8月前有关DYX1C1基因1249G>T多态性与阅读障碍易感性关系的病例对照研究及以家系为基础的传递/不平衡检验(TDT),采用Catmap软件包进行Meta分析。结果该研究共纳入文献7篇。合并病例对照研究和TDT研究的Meta分析结果显示,合并后OR值为0.68(95%CI=0.28～1.65,P=0.394)。亚组分析结果显示,病例对照研究合并后OR值为1.15(95%CI=0.74～1.79,P=0.522);TDT研究合并后OR值为0.31(95%CI=0.07～1.41,P=0.130)。敏感性分析进一步表明该结果稳定性较好。结论该研究提示DYX1C1基因1249G>T多态性与阅读障碍易感性不存在明显关联。

Objective To evaluate the association between DYX1C1 1249GT polymorphism and dyslexia susceptibility.Methods Multiple electronic databases were searched to identify studies assessing the 1249GT variant in dyslexia.Data from case-control and TDT studies were analyzed in an allelic model using the Catmap software.Results Seven studies were included in this meta-analysis according to the selection criteria.The combined result of case-control and TDT studies showed that no significant association was found between the allelic variant and dyslexia risk（OR=0.68,95% CI=0.28-1.65,P=0.394）.Additionally,the stratified analysis was performed by study design.The 1249GT was not associated with dyslexia both in case-control studies and in TDT studies（case-control studies：OR=1.15,95% CI=0.74-1.79,P=0.522;TDT studies：OR=0.31,95% CI=0.07-1.41,P=0.130）.Moreover,the sensitive analysis indicated the stability of the results.Conclusion This meta-analysis revealed that the DYX1C1 1249GT polymorphism might not contribute to the susceptibility of dyslexia.