肝硬化CT改变与Child-Pugh分级相关性的初步研究

Primary study on the relationship between CT manifestation and Child-Pugh classification of liver cirrhosis

目的探讨肝硬化的肝脏形态、侧支循环、腹水、脾脏以及胆囊等CT改变与肝功能Child-Pugh分级的相关性。寻找对肝功能最有评价价值的CT表现,以期为肝硬化的肝功能评价、治疗和疗效观察提供帮助。方法回顾性分析确诊为肝硬化的99例住院病人的肝功能(Child-Pugh分级:A18.2%,Child-PughB41.4%,Child-PughC40.4%)及CT检查结果 ,探讨肝硬化患者的CT表现与Child-Pugh分级的关系。肝硬化CT表现纳入参数的有形态改变、侧支循环、腹水、脾大、胆囊改变。将上述观察指标与Child-Pugh分级作对照研究和统计学分析。结果肝脏CT形态改变和胆囊改变与Child-Pugh分级呈明显相关性;侧支循环、脾大与Child-Pugh分级相关性不大。结论肝硬化CT改变能提示肝功能状态,有望作为Child-Pugh分级的有益补充。

Objective To explore the relationship between CT change of liver morphology, portal hypertension, ascites, spleen and gallbladder, and Child - Pugh classification of liver function, searching the CT manifestation of best assessing value, then help to evaluate the liver function, therapy and observation of therapeutic effect. Methods 99 cases of liver cirrhosis that hospitalized and diagnosed between 2006 and 2009 were enrolled into the study, analyses retrospectively on the liver function （Child- Pugh classification： A 18.2%, child- phgh B 41.4%, child- pugh C 40.4% ） and CT results, explored the relationship between CT manifestation. The parameters assessing cirrhosis included the change of liver morphology, splenomegaly, ascites, collateral pathways and change of gallbladder, and then compared with Child - Pugh classification. Results There＇ s obvious relationship between the change of liver morphology, cystic change and Child - Pugh classification, but less relationship between splenomegaly, ascites, collateral pathways and Child - Pugh classification Conclusion Contour irregularities of the liver could be a suggestion of the liver function, and be hopeful to be a helpful complement of Child - Pugh classification.