2型糖尿病并发消化性溃疡的难治因素分析

Analysis of the refractoriness factor of type-2 diabetes mellitus complicated peptic ulcer

目的探讨2型糖尿病并发消化性溃疡的难治因素。方法选取2型糖尿病并消化性溃疡患者114例设为观察组,并随机选择同期非糖尿病的消化性溃疡患者120例作为对照组。分析2组溃疡愈合率和幽门螺杆菌(Hp)感染率及阴转率。结果观察组溃疡治愈率、Hp感染率及转阴率均差于对照组,差异均有统计学意义(P<0.01)。观察组50岁以上年龄段溃疡愈合率为42.9%低于50岁以下年龄段者的57.1%,差异有统计学意义(P<0.01);对照组两年龄段溃疡愈合率比较差异无统计学意义(P>0.05)。结论胃血管病变、胃自主神经病变、Hp感染及病程(年龄)是糖尿病合并消化性溃疡的难治因素。

Objective To discuss the refractoriness factor of type-2 diabetes mellitus complicated peptic ulcer.Methods 114 cases patients with type-2 diabetes mellitus complicated peptic ulcer were selected for the observation group,randomly selected 120 cases patients with non-diabetes mellitus complicated peptic ulcer as control group.Analyzed of ulcer healing rate and helicobacter pylori（Hp） infection rate and conversion rate.Results Ulcer healing rate,Hp infection rate and conversion rate of observation group were badder than those of control group（P〈0.01）.The ulcer healing rate of over 50 years age patients of observarion group（42.9%） was lower than that of low 50 years age patients（57.1%）,the difference was statistically significant（P〈0.01）;Compared the ulcer healing rate of two age bracket of control group,the difference was not statistically significant（P〉0.05）.Conclusion Gastric vascular disease,stomach autonomic neuropathy,Hp infection and disease course（age） are refractoriness factor in patient with diabetes mellitus complicated peptic ulcer.