摘要
目的建立HPLC法测定克霉唑乳膏含量的不确定度分析方法。方法通过建立HPLC含量测定法的数学模型,找出影响不确定度的因素并对各个不确定度分量进行评定。结果计算各分量的相对标准不确定度,由此计算合成不确定度和扩展不确定度,从结果可看出对照品带来的不确定性较大。结论测量不确定度可用于对克霉唑乳膏含量测定结果的评定。
Objective To estabhsh an uncertainty analysis method for Clotrimazole cream by HPLC. Methods The mathematic mod- el was established by HPLC identified the influence factors impact uncertainty and each component of uncertainty was also evaluated. Results Each component of uncertainty was calculated by analyzing the various variable parameters in the procedure,the combined uncertainty and expanded uncertainty were finally obtained. The results showed the control brought greater uncertainty. Conclusion The mathematic model of uncertainty is establish for applicable to evaluate the accuracy of assay of Clotrimazole cream.
出处
《中国现代医生》
2011年第36期78-79,共2页
China Modern Doctor
